IDD-8E
IDD-8E is an effective anti-pseudomonal agent (MIC =4.4 µM ) with no cytotoxicity. IDD-8E shows significant pseudomonal killing and disruption of pseudomonal biofilm. IDD-8E binds to the ATP-binding pocket of WaaP and also inhibits other ESKAPE pathogens.
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- Formule: C21H20N6O3
- Masse moléculaire:404.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IDD-8E (10-100 µM; 24 h) remains unchanged at higher concentrations compared to untreated controls using RAW cells, showing no cytotoxicity[1].
IDD-8E (2, 4.4 µM; 0-5 h) is observed to significantly reduce the number of Pseudomonas aeruginosaand and is as effective as Rifampicin (HY-B0272). It is also found to have the ability to disrupt biofilm[1].
IDD-8E is synergistic with each of the three antibiotics (Rifampicin (HY-B0272), Lincomycin (HY-117660), Carbenicillin (HY-B0525)) in several combinations. Synergistic combinations effectively reduces the minimum inhibitory concentrations (MICs) of the antibiotics[1].
IDD-8E can inhibit the growth of other ESKAPE pathogens, with MIC values of 6.25 µM, 50 µM, 12.5 µM,12.5 µM and 50 µM against A. baumannii, K. pneumoniae, Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant Enterococcus faecalis (VRE) and E. coli, respectively [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW cells
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Concentration:100 µM, 70 µM, 40 µM, and 10 µM
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Incubation Time:24 h
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Result:IDD-8E showed no significant cytotoxic effects at the concentrations tested, similar to the negative control, Rifampicin. This indicates that IDD-8E is potentially safe for further development as it does not harm the macrophage cells at effective antibacterial concentrations.
Chemical Information
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Masse moléculaire 404.42
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Formule C21H20N6O3
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SMILES
CC(C=C1)=CC2=C1N=C(NC3=NC(C4=CC(OC)=C(OC)N=C4)=CC(N3)=O)N=C2C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IDD-8E Related Classifications
HY-161395 Related Classifications
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