Isotetrandrine
Based on 3 publication(s) in Google Scholar
Isotetrandrine is a bioactive component in Stephania tetrandra.
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- Pureté: 95.56%
- CAS No.: 477-57-6
- Formule: C38H42N2O6
- Masse moléculaire:622.75
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Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Isotetrandrine
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | ED50 |
8.4 μg/mL
Compound: 4
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Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay
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[PMID: 8450319] |
| HT-1080 | ED50 |
11 μg/mL
Compound: 4
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Cytotoxicity against human HT1080 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human HT1080 cells after 3 days by sulforhodamine B assay
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[PMID: 8450319] |
| KB | ED50 |
10 μg/mL
Compound: d-Tetrandrine
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 7130986] |
| KB | ED50 |
10600 nM
Compound: 18
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Cytotoxicity against human KB cells after 72 hrs by SRB assay
Cytotoxicity against human KB cells after 72 hrs by SRB assay
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[PMID: 9917283] |
| KB | ED50 |
6.6 μg/mL
Compound: 4
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Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay
Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay
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[PMID: 8450319] |
| KB-V1 | ED50 |
1.5 μg/mL
Compound: 4
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Cytotoxicity against human KBV1 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human KBV1 cells after 3 days by sulforhodamine B assay
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[PMID: 8450319] |
| LNCaP | ED50 |
9.4 μg/mL
Compound: 4
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Cytotoxicity against human LNCAP cells after 3 days by sulforhodamine B assay
Cytotoxicity against human LNCAP cells after 3 days by sulforhodamine B assay
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[PMID: 8450319] |
| P388 | ED50 |
5.6 μg/mL
Compound: 4
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Cytotoxicity against mouse P388 cells after 2 days by sulforhodamine B assay
Cytotoxicity against mouse P388 cells after 2 days by sulforhodamine B assay
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[PMID: 8450319] |
| SK-MEL-2 | ED50 |
19.5 μg/mL
Compound: 4
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Cytotoxicity against human SK-MEL-2 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human SK-MEL-2 cells after 3 days by sulforhodamine B assay
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[PMID: 8450319] |
| ZR-75-1 | ED50 |
5 μg/mL
Compound: 4
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Cytotoxicity against human ZR-75-1 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human ZR-75-1 cells after 3 days by sulforhodamine B assay
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[PMID: 8450319] |
Fangchi, derived from the rhizoma of S. acutum and the radix of S. tetrandra and S. acutum, has been widely used for the treatment of rheumatic arthritis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 477-57-6
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Appearance Solid
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Masse moléculaire 622.75
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Formule C38H42N2O6
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Color White to light yellow
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SMILES
COC1=C(O2)C3=C(C=C1OC)CCN(C)[C@]3([H])CC4=CC=C(OC)C(OC5=CC=C(C=C5)C[C@@]6([H])C7=C(CCN6C)C=C(OC)C2=C7)=C4
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (3)
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Journal Impact Factor
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Most Recent
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J Virol
Bis-benzylisoquinoline alkaloids inhibit African swine fever virus internalization and replication by impairing late endosomal/lysosomal function. [Abstract]2024 Jul 31:e0032724. PMID: 39082785 -
Virol J
Bisbenzylisoquinoline alkaloids inhibit influenza virus replication by disrupting endosomal acidification. [Abstract]2025 Jun 4;22(1):181. PMID: 40468427 -
Protein J
Multi-scale In Silico and Biochemical Evaluation of Natural Bisbenzylisoquinoline Alkaloids as Aldose Reductase Inhibitors. [Abstract]2025 Nov 8. PMID: 41206377
Pureté et documentation
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Fiche technique (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Isotetrandrine Related Classifications
HY-N6045 Related Classifications
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