Iturin A
Based on 1 publication(s) in Google Scholar
Iturin A is a cyclic lipid peptide with strong antifungal activity. Iturin A induces ROS explosion and induces apoptosis and autophagy in tumor cells. Iturin A has antitumor activity.
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- Pureté: 98.53%
- CAS No.: 52229-90-0
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Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Iturin A
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Activité biologique
Iturin A (5-250 µg/mL;12 h) significantly inhibits Fusarium graminearum conidial activity at a concentration of 5 µg/mL, and completely inhibits conidial germination at 50 µg/mL[1].
Iturin A (0-100 μM; 48 h) inhibits cell growth, induces cell cycle arrest, ROS outburst, apoptosis and autophagy in HepG2 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2
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Concentration:5, 10, 25, 50, 75 and 100 μM
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Incubation Time:48 h
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Result:Inhibited the growth of HepG2 cells in a concentration dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HepG2 cells treated female BALB/c nude mice aged 4 weeks old[2]
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Dosage:3 mg/kg
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Administration:15 days
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Result:Significantly inhibited tumor growth.
Induced apoptosis and autophagy of tumor cells.
Improved the tumor immune microenvironment.
Had no significant influence on body weight, food intake, and viscera index in mice
Interfered with the liver function of mice, but has no significant effect on the renal function.
Was safe to kidney and spleen.
Chemical Information
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CAS No. 52229-90-0
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Appearance Solid
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Color White to off-white
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Sequence
cyclo[D-Asn-Gln-Pro-D-Asn-Ser-Unk-Asn-D-Tyr]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvant et solubilité
Ethanol : 5 mg/mL (Need ultrasonic)
H2O : 1 mg/mL (Need ultrasonic)
Pureté et documentation
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Fiche technique (285 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Gong AD, et al. Antagonistic mechanism of iturin A and plipastatin A from Bacillus amyloliquefaciens S76-3 from wheat spikes against Fusarium graminearum. PLoS One. 2015 Feb 17;10(2):e0116871. [Content Brief]
[2]. Zhao H, et al. Effects of Bacillus subtilis iturin A on HepG2 cells in vitro and vivo. AMB Express. 2021 May 10;11(1):67. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Iturin A Related Classifications
HY-P2322 Related Classifications
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