JGB-1-155
JGB-1-155 is a nicotinamide phosphoribosyltransferase (NAMPT) activator and also a reactive oxygen species (ROS) inhibitor. JGB-1-155 binds to NAMPT, thereby enhancing its catalytic activity and increasing intracellular NAD+ levels. JGB-1-155 alleviates the elevation of ROS levels induced by various types of damage. JGB-1-155 can be used in research related to neurodegenerative diseases.
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- CAS No.: 3011930-28-9
- Formule: C26H38N2O3
- Masse moléculaire:426.59
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
EC50: NAMPT (3.29 μM)
JGB-1-155 exerts positive allosteric regulation on purified NAMPT, with an EC50 of 3.29 μM and a maximum activation fold of 1.41[1].
JGB-1-155 (3-40 μM) increases NAD+ levels in human THP-1 monocytes in a concentration-dependent manner by directly activating NAMPT[1].
JGB-1-155 activates purified NAMPT enzyme with an EC50 of 3.88 μM[2].
JGB-1-155 (20-40 μM) attenuates TNFα-induced mitochondrial ROS production in mouse HT-22 hippocampal neuron cells in a concentration-dependent manner[1].
JGB-1-155 (1.25-40 μM) attenuates glutamate-induced mitochondrial ROS in mouse HT-22 hippocampal neuron cells in a concentration-dependent manner[1].
JGB-1-155 (1.25-20 μM; overnight pre-incubation; overnight insult incubation) reduces ROS levels in HT-22 cells exposed to VK3, glutamate, TNFα or hyperconfluent conditions in a dose-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3011930-28-9
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Masse moléculaire 426.59
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Formule C26H38N2O3
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SMILES
O=C(N(CCC1(C(C)C)CCOC(C)(C1)C)CC2=CC=C(N(C)C)C=C2)C3=CC=CO3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JGB-1-155 Related Classifications
HY-163280 Related Classifications
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