JLJ648
JLJ648 is a Gag-Pol dimerizer with antiviral activity. JLJ648 can inhibit HIV replication and induce infected cell pyroptosis. JLJ648 can be used for the research of infection, such as HIV (human immunodeficiency virus).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C23H17N3O3S
- Masse moléculaire:415.46
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
JLJ648 (3 days) inhibits HIV-1 replication in MT-2 cells with an EC50 of 1.6 nM[1].
JLJ648 shows low cytotoxicity in MT-2 and THP-1 cells (CC50>100 μM) and a CC50 of 22.9 μM in primary CD4+ T cells[1].
JLJ648 (17 h) promotes the homodimerization of recombinant HIV-1 RT p66 subunit with an EC50 of 95 nM[1].
JLJ648 (3-4 h) induces HIV protease-dependent pyroptosis in THP-1 clone14 cells and HIV-infected primary CD4+ T cells, with an EC50 of 86 nM[1].
JLJ648 (50 μM, 12 h) binds to HIV-1 RT p66 to form two oligomeric structures, subunits in catalytic/structural conformations and "infinity knot"-shaped homotetramer[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 415.46
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Formule C23H17N3O3S
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SMILES
S=C(N1)C=CN(CCOC2=C(OC3=CC=CC4=C3C=CC(C#N)=C4)C=CC=C2)C1=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JLJ648 Related Classifications
HY-178201 Related Classifications
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