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Cat. No.: HY-147849

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JMI-105

JMI-105 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-105 inhibits the growth of CQ^S (3D7; IC₅₀=8.8 µM) and CQ^R (RKL-9; IC₅₀=14.3 µM) strains of P. falciparum. JMI-105 significantly decreases parasitemia and prolonged host survival in a murine model with P. berghei ANKA infection. JMI-105 has the potential to be used as an anti-malarial agent.

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CAS No.: 2227315-30-0
Formule: C₂₀H₂₃N₃O₂
Masse moléculaire:337.42

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

JMI-105 Chemical Structure

CAS No.: 2227315-30-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Chemical Information

CAS No. 2227315-30-0
Masse moléculaire 337.42
Formule C₂₀H₂₃N₃O₂
SMILES

CC(C1=CC=C(C)C(OCC2=CN(C3=CC=C(OC)C=C3)N=N2)=C1)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Uddin A, et al. Identification and structure-activity relationship (SAR) studies of carvacrol derivatives as potential anti-malarial against Plasmodium falciparum falcipain-2 protease. Bioorg Chem. 2020 Oct;103:104142. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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JMI-105

Voir tous les produits spécifiques à Isoform Parasite

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

JMI-105 Related Classifications

HY-147849 Related Classifications