KIT-13
KIT-13 is an orally active plasmalogen derivative to inhibit neuroinflammation and mitochondrial DNA leakage associated with Mecp2 deficiency. KIT-13 significantly reduce neurological symptoms and improves the life span of the Rett Syndrome (RTT) model mice. KIT-13 can be used for the study of RTT and other neuroinflammation-related diseases.
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- Formule: C43H80NO7P
- Masse moléculaire:754.07
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
KIT-13 (5-10 g/mL, 48 h, BV2 cells) ameliorates mitochondrial functional deficits induced by Mecp2 gene deletion and mitochondrial membrane potential in Mecp2-KD BV2 cells is restored by treatment with PK11195 (HY-19567) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mecp2-knockdown BV2 cells
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Concentration:
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Incubation Time:48 h
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Result:Decreased levels of four different mtDNA-specific genes (Mt-Rnr2, MT-Co1, Mt-Nd2, Mt-Cytb).
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Cell Line:BV2 cells
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Concentration:5 µg/mL
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Incubation Time:48 h
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Result:Reduced TSPO expression.
KIT-13 (20 μg/kg, p.o., 6 weeks, daily) improves neurological symptoms and restores healthy microglia morphology in RTT mice brain tissue[1].
KIT-13 (p.o., 2 weeks, daily ) attenuates abnormalities in social and anxiety-like behavior in RTT model mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mecp2-KO in C57BL/6 mice (4 weeks)
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Dosage:20 μg/kg
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Administration:Daily oral administration 6 weeks
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Result:Improved the survival of Mecp2-KO mice and reduced the RTT neurological symptom score including improvement of the general condition of the Mecp2-KO mice more effectively compared with Plasmaloge, KIT-08, KIT19 or KIT20.
Reduced the soma size and increased the dendrite length in the Mecp2-KO mice, partially restoring a healthy phenotype.
Chemical Information
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Masse moléculaire 754.07
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Formule C43H80NO7P
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SMILES
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(O[C@@H](CO[P@]([O-])(OCC[NH3+])=O)COCCCCCCCCCCCCCCCCCC)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KIT-13 Related Classifications
HY-176266 Related Classifications
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