Komaroidine
Komaroidine is a bactericidal agent. Komaroidine induces reactive oxygen species (ROS) bursts in bacterial cells, disrupts antioxidant enzyme function and redox homeostasis, increases membrane permeability, and triggers bacterial apoptosis. Komaroidine suppresses bacterial burden within infected plant tissues.Komaroidine exhibits broad-spectrum antibacterial activity against phytopathogenic bacteria including Xanthomonas oryzae pv. oryzae, Xanthomonas axonopodis pv. citri, and Pseudomonas syringae pv. actinidiae. Komaroidine can be used for the research of rice bacterial leaf blight.
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- CAS No.: 6649-76-9
- Formule: C14H18N2
- Masse moléculaire:214.31
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Komaroidine (compound B2) potently inhibits Xoo, Xac, and Psa with EC50 values of 1.12 μg/mL, 4.85 μg/mL, and 20.08 μg/mL, respectively[1].
Komaroidine (12.5-50.0 μg/mL; 15 h) induces dose-dependent ROS accumulation in Xoo cells, with a 4.1-fold increase at 50.0 μg/mL[1].
Komaroidine (3.125-50.0 μg/mL) disrupts antioxidant enzyme activity in Xoo cells, with complete SOD inactivation and declining CAT activity at concentrations ≥12.5 μg/mL[1].
Komaroidine (25.0 μg/mL) synergistically enhances Xoo sensitivity to 0.05 mM H2O2, completely suppressing bacterial growth[1].
Komaroidine (12.5-50.0 μg/mL; 15 h) induces dose-dependent apoptosis in Xoo cells, with a 56.90% total apoptotic rate at 50.0 μg/mL, and increases membrane permeability in Xoo cells in a dose-dependent manner[1].
Komaroidine (compound B2) (25.0 μg/mL; 15 h) alters the transcriptome of Xoo PXO99A cells, affecting metabolic, stress, and apoptosis-related pathways[1].
Komaroidine (compound B2) (200 μg/mL; pot experiment application) exhibits superior in vivo control efficacy against rice bacterial leaf blight (BLB) by significantly reducing bacterial burden in infected tissues[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 6649-76-9
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Masse moléculaire 214.31
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Formule C14H18N2
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SMILES
CCCC(NCC1)C2=C1C3=CC=CC=C3N2
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Liu HW, et al. Natural product scaffold-based bactericide discovery: novel β-carboline derivatives as potent reactive oxygen species inducers for crop disease control. Pest Manag Sci. Published online January 10, 2026. [Content Brief]
[2]. Tulyaganov, et al. Alkaloids from plants of the genus Nitraria. Chem Nat Compd 42, 198-200 (2006).
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Komaroidine Related Classifications
HY-N18435 Related Classifications
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- Komaroidine
- 6649-76-9
- Bacterial
- Reactive Oxygen Species (ROS)
- reactive oxygen species
- Nitraria komarovii
- rice bacterial leaf blight
- phytopathogenic bacteria
- Nitraria schoberi
- Pseudomonas syringae pv. actinidiae
- bacterial apoptosis
- Xanthomonas axonopodis pv. citri
- redox homeostasis
- Xanthomonas oryzae pv. oryzae
- Inhibitor
- inhibitor
- inhibit