KU-0058684
Based on 1 Customer Validation
KU-0058684 is a potent PARP inhibitor, with an IC50 of 3.2 nM for PARP-1. KU-0058684 significantly reduces DNA double strand break (DSB) repair.
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- Pureté: 98.54%
- CAS No.: 623578-11-0
- Formule: C19H14FN3O3
- Masse moléculaire:351.33
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
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PARP-1 3.2 nM (IC50) |
Chemical Information
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CAS No. 623578-11-0
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Appearance Solid
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Masse moléculaire 351.33
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Formule C19H14FN3O3
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Color White to off-white
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SMILES
O=C(N1C2=CC(CC3=NNC(C4=C3C=CC=C4)=O)=CC=C2F)CCC1=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : ≥ 100 mg/mL (284.63 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Mitchell J, et al. Poly(ADP-Ribose) polymerase-1 and DNA-dependent protein kinase have equivalent roles in double strand break repair following ionizing radiation. Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1520-7. [Content Brief]
[2]. McCabe N, et al. BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency. Cancer Biol Ther. 2005 Sep;4(9):934-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.8463 mL | 14.2316 mL | 28.4633 mL | 71.1582 mL |
| 5 mM | 0.5693 mL | 2.8463 mL | 5.6927 mL | 14.2316 mL | |
| 10 mM | 0.2846 mL | 1.4232 mL | 2.8463 mL | 7.1158 mL | |
| 15 mM | 0.1898 mL | 0.9488 mL | 1.8976 mL | 4.7439 mL | |
| 20 mM | 0.1423 mL | 0.7116 mL | 1.4232 mL | 3.5579 mL | |
| 25 mM | 0.1139 mL | 0.5693 mL | 1.1385 mL | 2.8463 mL | |
| 30 mM | 0.0949 mL | 0.4744 mL | 0.9488 mL | 2.3719 mL | |
| 40 mM | 0.0712 mL | 0.3558 mL | 0.7116 mL | 1.7790 mL | |
| 50 mM | 0.0569 mL | 0.2846 mL | 0.5693 mL | 1.4232 mL | |
| 60 mM | 0.0474 mL | 0.2372 mL | 0.4744 mL | 1.1860 mL | |
| 80 mM | 0.0356 mL | 0.1779 mL | 0.3558 mL | 0.8895 mL | |
| 100 mM | 0.0285 mL | 0.1423 mL | 0.2846 mL | 0.7116 mL |
KU-0058684 Related Classifications
HY-123232 Related Classifications
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