L-162313
Based on 1 Customer Validation
L-162313 is a non-peptide angiotensin II AT1 and AT2 receptor agonist, with IC50 values of 1.1 and 2.0 nM for AT1 and AT2 receptor, respectively. L-162313 can be used for the research of vasoconstriction, aldosterone release, and cardiovascular growth.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.51%
- CAS No.: 151488-11-8
- Formule: C30H38N4O4S2
- Masse moléculaire:582.78
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Voir tous les produits spécifiques à Isoform Angiotensin Receptor
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COS-7 | IC50 |
1.1 nM
Compound: L-162313
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Displacement of [125I]angiotensin 2 from rat AT1 receptor expressed in african green monkey COS7 cells after 24 hrs
Displacement of [125I]angiotensin 2 from rat AT1 receptor expressed in african green monkey COS7 cells after 24 hrs
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[PMID: 20493713] |
| COS-7 | IC50 |
2 nM
Compound: L-162313
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Displacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrs
Displacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrs
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[PMID: 20493713] |
Chemical Information
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CAS No. 151488-11-8
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Appearance Solid
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Masse moléculaire 582.78
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Formule C30H38N4O4S2
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Color Off-white to light yellow
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SMILES
O=C(NS(=O)(C1=C(C2=CC=C(CN3C4=NC(C)=CC(C)=C4N=C3CC)C=C2)C=C(CC(C)C)S1)=O)OCCCC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 100 mg/mL (171.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.7159 mL | 8.5796 mL | 17.1591 mL | 42.8978 mL |
| 5 mM | 0.3432 mL | 1.7159 mL | 3.4318 mL | 8.5796 mL | |
| 10 mM | 0.1716 mL | 0.8580 mL | 1.7159 mL | 4.2898 mL | |
| 15 mM | 0.1144 mL | 0.5720 mL | 1.1439 mL | 2.8599 mL | |
| 20 mM | 0.0858 mL | 0.4290 mL | 0.8580 mL | 2.1449 mL | |
| 25 mM | 0.0686 mL | 0.3432 mL | 0.6864 mL | 1.7159 mL | |
| 30 mM | 0.0572 mL | 0.2860 mL | 0.5720 mL | 1.4299 mL | |
| 40 mM | 0.0429 mL | 0.2145 mL | 0.4290 mL | 1.0724 mL | |
| 50 mM | 0.0343 mL | 0.1716 mL | 0.3432 mL | 0.8580 mL | |
| 60 mM | 0.0286 mL | 0.1430 mL | 0.2860 mL | 0.7150 mL | |
| 80 mM | 0.0214 mL | 0.1072 mL | 0.2145 mL | 0.5362 mL | |
| 100 mM | 0.0172 mL | 0.0858 mL | 0.1716 mL | 0.4290 mL |
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