L-690330
Based on 1 publication(s) in Google Scholar
L-690330 is a competitive inhibitor of inositol monophosphatase (IMPase) with Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively. L-690330 exhibits 10-fold more sensitive than mouse and rat IMPase.
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- Pureté: 99.70%
- CAS No.: 142523-38-4
- Formule: C8H12O8P2
- Masse moléculaire:298.12
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) L-690330
More
Activité biologique
Ki: 0.27 μM (Recombinant human IMPase), 0.19 μM (Recombinant bovine IMPase), 0.30 μM (Human frontal cortex IMPase), 0.42 μM (Bovine frontal cortex IMPase)[1]
L-690330 (50 μM; 1 hour) induces P-AMPK and autophagy and increases LC3-I/II and p-AMPK expression in HEK293 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293 cells
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Concentration:50 μM
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Incubation Time:1 hour
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Result:Improved LC3-I/II and p-AMPK protein level.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Eight-week-old male ICR mice[3]
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Dosage:0.1 μmol
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Administration:Intracerebroventricular injection
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Result:Did not effect mice well-being by i.c.v injection.
Chemical Information
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CAS No. 142523-38-4
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Appearance Solid
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Masse moléculaire 298.12
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Formule C8H12O8P2
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Color White to off-white
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SMILES
OC1=CC=C(OC(P(O)(O)=O)(P(O)(O)=O)C)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Sci Rep
2025 Dec 29;15(1):44762. PMID: 41461699
Solvant et solubilité
H2O : 66.67 mg/mL (223.63 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Atack JR, et al. In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J Neurochem. 1993 Feb;60(2):652-8. [Content Brief]
[2]. Cárdenas C, et al. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.Cell. 2010 Jul 23;142(2):270-83. [Content Brief]
[3]. Shtein L, et al. The inositol monophosphatase inhibitor L-690,330 affects pilocarpine-behavior and the forced swim test.Psychopharmacology (Berl). 2013 Jun;227(3):503-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.3544 mL | 16.7718 mL | 33.5435 mL | 83.8589 mL |
| 5 mM | 0.6709 mL | 3.3544 mL | 6.7087 mL | 16.7718 mL | |
| 10 mM | 0.3354 mL | 1.6772 mL | 3.3544 mL | 8.3859 mL | |
| 15 mM | 0.2236 mL | 1.1181 mL | 2.2362 mL | 5.5906 mL | |
| 20 mM | 0.1677 mL | 0.8386 mL | 1.6772 mL | 4.1929 mL | |
| 25 mM | 0.1342 mL | 0.6709 mL | 1.3417 mL | 3.3544 mL | |
| 30 mM | 0.1118 mL | 0.5591 mL | 1.1181 mL | 2.7953 mL | |
| 40 mM | 0.0839 mL | 0.4193 mL | 0.8386 mL | 2.0965 mL | |
| 50 mM | 0.0671 mL | 0.3354 mL | 0.6709 mL | 1.6772 mL | |
| 60 mM | 0.0559 mL | 0.2795 mL | 0.5591 mL | 1.3976 mL | |
| 80 mM | 0.0419 mL | 0.2096 mL | 0.4193 mL | 1.0482 mL | |
| 100 mM | 0.0335 mL | 0.1677 mL | 0.3354 mL | 0.8386 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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