LPPM-8
LPPM-8 is a ligand of Med25 and an inhibitor of Med25 protein-protein interactions (PPIs). LPPM-8 engages Med25 through interaction with the H2 face of its Activator Interaction Domain and stabilizes full-length protein in the cellular proteome. LPPM-8 is an orthosteric inhibitor of H2-binding transcriptional activators (such as ATF6a). LPPM-8 can be used for studying Med25 and Mediator complex biology.
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- Formule: C50H89N7O14
- Masse moléculaire:1012.28
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Med25 is a substoichiometric component of the megadalton Mediator complex and serves to bridge Mediator and transcriptional activators during transcription initiation through PPIs with the amphipathic ETV/PEA3 family (cell migration, motility), ATF6a (stress response), and VP16 (viral infection)[1].
LPPM-8 (10 and 20 μM) inhibits a Med25-dependent gene (MMP-9) in VARIO68 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 1012.28
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Formule C50H89N7O14
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Sequence
{(2S,3R)-3-Hydroxy-2-methylundecanoyl}-{d-(Glu-Asp-Leu-Leu-Leu-Leu-Val)}
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Sequence Shortening
{(2S,3R)-3-Hydroxy-2-methylundecanoyl}-{d-(EDLLLLV)}
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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