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Cat. No.: HY-184003

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LY3972406

LY3972406 is an orally active, selective Kv1.3 antagonist. LY3972406 acts on chronically stimulated effector memory T cells without affecting naive central memory T cells. LY3972406 induces mild, non-adverse skin irritation in Rattus norvegicus. LY3972406 is applicable for the research of autoimmune diseases.

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CAS No.: 3071928-57-6
Formule: C₁₆H₂₃ClN₂O₄·1/2C₅H₈O₄·1/2H₂O
Masse moléculaire:492.95

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LY3972406 Chemical Structure

CAS No.: 3071928-57-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

Kv1.3

In Vivo

LY3972406 (300 mg/kg/day; p.o.; daily; 28 days) at 300 mg/kg/day (administered as the HG salt) is well-tolerated in Sprague-Dawley rats over 28 days, with nonadverse salivation and equivalent exposure to the HCl salt form^[2].
LY3972406 (100 mg/kg; p.o.; single dose) achieves equivalent exposure to the HCl salt in female Sprague-Dawley rats, with slightly faster absorption^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (male and female, aged 7 to 11 weeks, males 187 to 514 g, females 146 to 308 g)^[2]
Dosage:

300 mg/kg/day
Administration:

p.o.; daily; 28 days
Result:

Observed 100% survival.
Caused minor, nonadverse salivation (slight intensity, Days 8 through 22) at similar incidence and severity as the LY3972406-HCl group.
Resulted in exposure comparable to the HCl salt (within 20% by AUC and C_max) with no accumulation (R_AUC <1.2).

Chemical Information

CAS No. 3071928-57-6
Masse moléculaire 492.95
Formule C₁₆H₂₃ClN₂O₄·1/2C₅H₈O₄·1/2H₂O
SMILES

ClC1=C(C)C=C(O)C([C@H](N)C2CCN(C([C@H](O)CO)=O)CC2)=C1.O=C(CCCC(O)=O)O.O.[1/2].[1/2]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Li X, et al. Development of a Scalable Manufacturing Process for Kv1. 3 Antagonist LY3972406 Hemiglutarate Hemihydrate[J]. Organic Process Research & Development, 2026.

[2]. Franklin KM, et al. Safety Evaluation of Glutaric Acid as a Novel Pharmaceutical Salt for First-In-Human Dosing. Toxicol Sci. 2026 May 21:kfag059. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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