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Cat. No.: HY-172374

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LY3972406 free base

LY3972406 free base is a kv1.3 potassium channel inhibitor without affecting hERG channel activity. LY3972406 free base can be used in research of immune-related diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.

For research use only. We do not sell to patients.

CAS No.: 2640023-16-9
Formula: C₁₆H₂₃ClN₂O₄
Molecular Weight:342.82

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

LY3972406 free base Chemical Structure

CAS No.: 2640023-16-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Kv1.3

In Vitro

LY3972406 free base (Compound I) inhibits the activity of the Kv1.3 potassium channel without blocking the hERG channel, resulting in reduced cardiotoxicity risk, enhanced ion channel selectivity, improved pharmacokinetic properties, and increased solubility^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2640023-16-9
Molecular Weight 342.82
Formula C₁₆H₂₃ClN₂O₄
SMILES

OC1=CC(C)=C(Cl)C=C1[C@H](N)C2CCN(C([C@@H](CO)O)=O)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. David Andrew Coates, et al. Solid forms of a kv1.3 potassium shaker channel blockers and method of using the same. WO2025029769A1. 2025-02-06

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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