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Cat. No.: HY-161377

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M4K2306

M4K2306 is a selective inhibitor for activin receptor-like kinase-2 (ALK2) with an IC₅₀ of 7 nM. M4K2306 is blood brain permeable with a brain to plasma ratio of 75.6.

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CAS No.: 3034840-25-7
Formule: C₂₈H₃₄N₄O₃
Masse moléculaire:474.59

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

M4K2306 Chemical Structure

CAS No.: 3034840-25-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

M4K2306 is a selective inhibitor for activin receptor-like kinase-2 (ALK2) with an IC₅₀ of 7 nM. M4K2306 is blood brain permeable with a brain to plasma ratio of 75.6^[1].

IC₅₀ & Target

ALK2

7 nM (IC₅₀)

ALK5

3915 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform TGF-β Receptor :

In Vivo

M4K2306 (25 mg/kg, po, single dose) exhibits exposure in plasma concentration C_max of 254 and 17 mM, at 1 hour and 24 hour in NOD-SCID mice model, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3034840-25-7
Masse moléculaire 474.59
Formule C₂₈H₃₄N₄O₃
SMILES

CN1CC(C(C2=CC(OC)=C(C(OC)=C2)OC)=CN=C3)=C3C4=CC=C(N5CCN(CC5)C)C=C4C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. González-Álvarez H, et al., Discovery of Conformationally Constrained ALK2 Inhibitors. J Med Chem. 2024 Mar 28;67(6):4707-4725. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Pureté et documentation
Références

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M4K2306

Voir tous les produits spécifiques à Isoform TGF-β Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

M4K2306 Related Classifications

HY-161377 Related Classifications