MD 220661
MD 220661 is a semicarbazide-sensitive amine oxidase (SSAO) and monoamine oxidase (MAO) inhibitor, and serves as a major metabolite of MD 240928 in rat brain. MD 220661 acts as a substrate for SSAO and exhibits reversible, selective MAO-B inhibition in rat tissues; in the absence of semicarbazide, its inhibitory potency against MAO-A activity decreases with prolonged pre-incubation time. MD 220661 is applicable to studies related to enzyme-catalyzed metabolism.
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- CAS No.: 73423-35-5
- Formule: C17H17ClN2O3
- Masse moléculaire:332.78
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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MAO-A |
MAO-B |
MD 220661 inhibits semicarbazide-sensitive amine oxidase in rat aorta homogenates with an initial IC50 of 3.0 μM, but its inhibitory potency decreases significantly with preincubation time, indicating it acts as both an inhibitor and substrate of the enzyme[1].
MD 220661 inhibits semicarbazide-sensitive amine oxidase in rat heart homogenates with an initial IC50 of 1.9 μM, and its inhibitory potency decreases with preincubation time, consistent with it acting as both an inhibitor and substrate of the enzyme[1].
MD 220661 inhibits monoamine oxidase A in rat aorta homogenates, and its inhibitory potency decreases significantly with preincubation time in the absence of semicarbazide, but only slightly in the presence of semicarbazide[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 73423-35-5
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Masse moléculaire 332.78
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Formule C17H17ClN2O3
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SMILES
O=C1OC(CN1C2=CC=C(C=C2)OCC3=CC=CC(Cl)=C3)CN
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MD 220661 Related Classifications
HY-124885 Related Classifications
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