MODAG-005
Based on 1 Customer Validation
MODAG-005 is a blood-brain barrier-permeable PET probe precursor for α-synuclein (α‑Syn) aggregates, with a Ki value of 0.4 nM and a Kd value of 0.2 nM. MODAG-005 specifically binds to high-affinity sites within the tubular cavity of α-synuclein fibrils, and exhibits selectivity over tau protein fibrils and β-amyloid (A1-42) fibrils. MODAG-005 is applicable to the research of multiple system atrophy and Parkinson's disease.
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- Pureté : 98.36%
- CAS No.: 2648041-73-8
- Formule: C15H13BrN4
- Masse moléculaire:329.19
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
α-synuclein Aggregation 0.2 nM (Kd) |
MAO-B 0.8 μM (IC50) |
In Vitro
[3H]MODAG-005 exhibits subnanomolar binding affinity for recombinant human α-synuclein fibrils, shows 36-fold lower affinity for tau fibrils and over 100-fold lower affinity for Aβ1-42 fibrils, with an MAO-B IC50 of 0.8 μM and no other relevant off-target binding[1].
[3H]MODAG-005 binds specifically to α-synuclein pathology in post-mortem human multiple system atrophy (MSA) brain tissues, with a high-affinity binding site (Kd = 0.19 nM); it shows no specific binding in control brain tissues and does not bind to monoamine oxidase B (MAO-B) in MSA tissues[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
[11C]MODAG-005 (intravenous administration; single bolus injection) binds specifically to α-synuclein fibrils in rats with striatal injections[1].
[11C]MODAG-005 (intravenous administration; single bolus injection) exhibits specific, pathology-associated binding to intracellular α-synuclein aggregates in α-SynA30P transgenic mice[1].
[11C]MODAG-005 (intravenous administration; single bolus injection) exhibits favorable pharmacokinetic properties in healthy cynomolgus monkeys, including rapid brain uptake, rapid clearance, and detectable plasma metabolism[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2648041-73-8
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Appearance Solid
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Masse moléculaire 329.19
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Formule C15H13BrN4
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Color Yellow to green
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SMILES
CNC1=CC=C(C=C1)C2=NNC(C3=CC=NC(Br)=C3)=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
In Vitro:
DMSO : 125 mg/mL (379.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0378 mL | 15.1888 mL | 30.3776 mL | 75.9440 mL |
| 5 mM | 0.6076 mL | 3.0378 mL | 6.0755 mL | 15.1888 mL | |
| 10 mM | 0.3038 mL | 1.5189 mL | 3.0378 mL | 7.5944 mL | |
| 15 mM | 0.2025 mL | 1.0126 mL | 2.0252 mL | 5.0629 mL | |
| 20 mM | 0.1519 mL | 0.7594 mL | 1.5189 mL | 3.7972 mL | |
| 25 mM | 0.1215 mL | 0.6076 mL | 1.2151 mL | 3.0378 mL | |
| 30 mM | 0.1013 mL | 0.5063 mL | 1.0126 mL | 2.5315 mL | |
| 40 mM | 0.0759 mL | 0.3797 mL | 0.7594 mL | 1.8986 mL | |
| 50 mM | 0.0608 mL | 0.3038 mL | 0.6076 mL | 1.5189 mL | |
| 60 mM | 0.0506 mL | 0.2531 mL | 0.5063 mL | 1.2657 mL | |
| 80 mM | 0.0380 mL | 0.1899 mL | 0.3797 mL | 0.9493 mL | |
| 100 mM | 0.0304 mL | 0.1519 mL | 0.3038 mL | 0.7594 mL |
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