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Cat. No.: HY-188585

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MP-Ala-Ala

MP-Ala-Ala is a protease-cleavable ADC Linker. MP-Ala-Ala can be stably conjugated to cysteine residues of targeting antibodies (such as anti-CD19 antibodies or anti-TNF antibodies). MP-Ala-Ala accelerates the hydrolysis and ring opening of the succinimide ring via MP to stabilize the antibody conjugation, and after entering the lysosome of target cells, the Ala-Ala dipeptide is cleaved by proteases, thereby targeting the release of the active payload to exert anti-inflammatory effects and reduce systemic toxicity. MP-Ala-Ala can be used in research on inflammatory and immune diseases.

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CAS No.: 3014393-33-7
Formule: C₁₃H₁₇N₃O₆
Masse moléculaire:311.29

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

MP-Ala-Ala Chemical Structure

CAS No.: 3014393-33-7

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform ADC Linkers :

In Vitro

MP-Ala-Ala can be used to construct anti-CD19 ADCs (such as ADC6 and ADC23)^[2].
MP-Ala-Ala can be used to construct anti-TNF ADCs (such as ADC39/ABBV-3373)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 3014393-33-7
Masse moléculaire 311.29
Formule C₁₃H₁₇N₃O₆
SMILES

O=C(N[C@@H](C)C(O)=O)[C@@H](NC(CCN1C(C=CC1=O)=O)=O)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Hobson AD, et al. Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate. Journal of medicinal chemistry. 2022 Dec 08;65(23):15893-15934. [Content Brief]

[2]. Marvin CC, et al. Self-Immolative Carbamate Linkers for CD19-Budesonide Antibody-Drug Conjugates. Bioconjug Chem. 2023 Oct 18;34(10):1835-1850. [Content Brief]

[3]. Hobson AD. The medicinal chemistry evolution of antibody-drug conjugates. RSC Med Chem. 2024 Feb 28;15(3):809-831.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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