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Cat. No.: HY-W347202

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N-Caffeoyl serotonin

N-Caffeoyl serotonin is a COX-2 inhibitor, with IC₅₀ and Kᵢ values of 42.5 μM and 65.5 μM against COX-2, respectively. N-Caffeoyl serotonin exhibits weak inhibitory activity against BACE1, with an IC₅₀ > 400 μM. N-Caffeoyl serotonin has free radical scavenging activity. N-Caffeoyl serotonin can be used in the research of allergic diseases and Alzheimer's disease.

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CAS No.: 928765-97-3
Formule: C₁₉H₁₈N₂O₄
Masse moléculaire:338.36

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

N-Caffeoyl serotonin Chemical Structure

CAS No.: 928765-97-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Protocole (2)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

^[2]

COX-2

42.5 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform COX :

Cellular Effect

Cell Line	Type	Value	Description	References
B16	IC₅₀	15 μM Compound: 3, N-caffeoylserotonin	Antimelanogenic activity in mouse B16 cells assessed as inhibition of intracellular melanin accumulation after 2 days Antimelanogenic activity in mouse B16 cells assessed as inhibition of intracellular melanin accumulation after 2 days	[PMID: 19524439]
B16	IC₅₀	28 μM Compound: 3, N-caffeoylserotonin	Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation	[PMID: 19524439]

In Vitro

N-caffeoyl serotonin exhibits excellent DPPH free radical scavenging activity (EC50 = 18.9 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 928765-97-3
Masse moléculaire 338.36
Formule C₁₉H₁₈N₂O₄
SMILES

C(CNC(/C=C/C1=CC(O)=C(O)C=C1)=O)C=2C=3C(NC2)=CC=C(O)C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology Animals and Diseases

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Takahashi T, et al. N-Caffeoyl serotonin as selective COX-2 inhibitor. Bioorg Med Chem Lett. 2012;22(7):2494-2496. [Content Brief]

[2]. Takahashi T, Miyazawa M. Serotonin derivatives as inhibitors of beta-secretase (BACE 1). Pharmazie. 2011 Apr;66(4):301-5. PMID: 21612159.
[Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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