NA-Ir
NA-Ir is a Ferroptosis inducer. NA-Ir targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to induce ferritinophagy (Autophagy), while also generating reactive oxygen species (ROS) through photodynamic therapy (PDT), depleting glutathione (GSH), and downregulating glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and Ferroptosis. NA-Ir exhibits higher anticancer activity under light exposure and selectively inhibits cancer cells with high H2S levels.
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- CAS No.: 3031762-97-4
- Formule: C49H36F6IrN8O4P
- Masse moléculaire:1138.04
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Chemical Information
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CAS No. 3031762-97-4
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Masse moléculaire 1138.04
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Formule C49H36F6IrN8O4P
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SMILES
CC1=CC2=[N](C=C1)[Ir+3]34([C-]5=C(C=CC=C5)C6=CC=CC=[N]63)([C-]7=CC=CC=C7C8=[N]4C=CC=C8)[N]9=CC=C(COC(CCN%10C(C%11=C%12C(C%10=O)=CC=C(C%12=CC=C%11)N=[N+]=[N-])=O)=O)C=C29.[F-][P+5]([F-])([F-])([F-])([F-])[F-]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (271 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NA-Ir Related Classifications
HY-162944 Related Classifications
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