NK037
NK037 is a phthalimide derivative that exhibits multi-target enzyme inhibitory activity against urease, xanthine oxidase, and butyrylcholinesterase (BChE). NK037 inhibits urease with IC50 = 2.9 μM, xanthine oxidase with IC50 = 5.61 μM, and butyrylcholinesterase with IC50 = 9.49 μM. NK037 can form enzyme-ligand complexes with urease, xanthine oxidase, and thymidine phosphorylase. Urease-IN-26 can be used for metabolism-related research.
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- CAS No.: 60945-03-1
- Formule: C15H8N2O2S
- Masse moléculaire:280.30
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
BChE 9.49 μM (IC50) |
In Vitro
NK037 (1‑8 μM) can bind to jack bean urease, bovine milk xanthine oxidase, and Escherichia coli thymidine phosphorylase, with dissociation constants Kd of 0.04 μM, 0.12 μM, and 0.49 μM, respectively, and binding constants Kb of 26.97 μM-1, 8.44 μM-1, and 2.03 μM-1, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 60945-03-1
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Masse moléculaire 280.30
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Formule C15H8N2O2S
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SMILES
O=C1N(C2=NC3=C(C=CC=C3)S2)C(C4=CC=CC=C41)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NK037 Related Classifications
HY-189733 Related Classifications
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Keywords
- NK037
- 60945-03-1
- NK 037
- NK-037
- Urease
- Xanthine Oxidase
- Drug Derivative
- Cholinesterase (ChE)
- Mycobacterium tuberculosis
- butyrylcholinesterase
- enzyme-ligand complexes
- nitrogen acquisition
- oxidative stress
- phagosomal alkalinization
- thymidine phosphorylase
- urease
- uric acid production
- xanthine oxidase
- Inhibitor
- inhibitor
- inhibit