country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-117744

Copy Link Print Information

NMS-P645

NMS-P645 is a PIM1 inhibitor. NMS-P645 exhibits anti-proliferative activity when combined with GDC-0941 (HY-50094) in TMPRSS2/ERG positive and negative PCa cells. NMS-P645 can reverse PIM1-induced pro-survival signals in prostate cells. NMS-P645 can be studied in research on prostate cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1482518-95-5
Formule: C₂₈H₃₈ClN₅O₂
Masse moléculaire:512.09

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

NMS-P645 Chemical Structure

CAS No.: 1482518-95-5

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Pim :

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	>10 μM Compound: 15a	Cytotoxicity against mouse BA/F3 cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against mouse BA/F3 cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
BaF3	IC₅₀	0.125 μM Compound: 15a	Cytotoxicity against mouse BA/F3 cells overexpressing PIM1 after 72 hrs by CellTitre-Glo assay Cytotoxicity against mouse BA/F3 cells overexpressing PIM1 after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
CAPAN-1	IC₅₀	3.704 μM Compound: 15a	Cytotoxicity against human Capan1 cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against human Capan1 cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
KMS-11	IC₅₀	7.134 μM Compound: 15a	Cytotoxicity against human KMS11 cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against human KMS11 cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
LNCaP	IC₅₀	3.313 μM Compound: 15a	Cytotoxicity against human LNCAP cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against human LNCAP cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
LP-1	IC₅₀	1.929 μM Compound: 15a	Cytotoxicity against human LP-1 cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against human LP-1 cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
MV4-11	IC₅₀	1.529 μM Compound: 15a	Cytotoxicity against human MV4-11 cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against human MV4-11 cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
NCI-H929	IC₅₀	5.928 μM Compound: 15a	Cytotoxicity against human NCI-H929 cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against human NCI-H929 cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
RPMI-8226	IC₅₀	6.658 μM Compound: 15a	Cytotoxicity against human RPMI8226 cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against human RPMI8226 cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]

Chemical Information

CAS No. 1482518-95-5
Masse moléculaire 512.09
Formule C₂₈H₃₈ClN₅O₂
SMILES

O=C(N[C@@H](C1CCCCC1)CN2CCN(C)CC2)C[C@H]3CNC(C4=CC(C5=CC=CC(Cl)=C5)=CN43)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Mologni, L., et al., (2017). The Novel PIM1 Inhibitor NMS-P645 Reverses PIM1-Dependent Effects on TMPRSS2/ERG Positive Prostate Cancer Cells And Shows Anti-Proliferative Activity in Combination with PI3K Inhibition. Journal of Cancer, 8(1), 140-145. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

NMS-P645

Voir tous les produits spécifiques à Isoform Pim

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

NMS-P645 Related Classifications

HY-117744 Related Classifications