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Cat. No.: HY-P3440A

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NOTA-WL12

NOTA-WL12 is a peptide-based imaging probe targeting PD-L1. NOTA-WL12 is a PD-L1 inhibitory peptide derivative and also a NOTA-conjugated WL12 precursor used for ⁶⁸Ga radiolabeling. The binding of NOTA-WL12 to human and mouse PD-L1 is evaluated by surface plasmon resonance. NOTA-WL12 is predicted by computational docking to interact with PD-L1.

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CAS No.: 2767203-39-2
Formule: C₁₁₁H₁₅₄N₂₆O₂₆S₂
Masse moléculaire:2332.70

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NOTA-WL12 Chemical Structure

CAS No.: 2767203-39-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

NOTA-WL12 (1 mg/mL; 15 min) is radiolabeled to [¹⁸F]AlF-NOTA-WL12 with a yield of 29% and a radiochemical purity of 97.3%^[2].
NOTA-WL12 (50 µg; 15 min) is radiolabeled with ⁶⁸Ga at 90°C, yielding ⁶⁸Ga-WL12 with a radiochemical purity of > 99% as determined by HPLC^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2767203-39-2
Masse moléculaire 2332.70
Formule C₁₁₁H₁₅₄N₂₆O₂₆S₂
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Yang Zhang, et al. PET Imaging of Peptide Probe Al[18F]F-NOTA-PCP1 for Monitoring the Engagement of PD-L1 Antibodies in Tumors. Mol. Pharmaceutics 4 March 2024; 21 (3): 1515-1525.

[2]. Ferro-Flores G, et al. Synthesis and Evaluation of [18F]AlF-NOTA-iPD-L1 as a Potential Theranostic Pair for [177Lu]Lu-DOTA-iPD-L1. Pharmaceutics. 2025 Jul 16;17(7):920. [Content Brief]

[3]. Li D, et al. Construction of an Iodine-Labeled CS1001 Antibody for Targeting PD-L1 Detection and Comparison with Low-Molecular-Peptide Micro-PET Imaging. Molecular pharmaceutics. 2022 Nov 07;19(11):4382-4389. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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