NSC 80467
Based on 1 Customer Validation
NSC 80467, a DNA damaging agent, selectively inhibits survivin. NSC 80467 preferentially inhibits DNA synthesis and results in induction of γH2AX and pKAP1, two markers of DNA damage.
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- Pureté: 98.39%
- CAS No.: 101982-51-8
- Formule: C24H22BrN3O5
- Masse moléculaire:512.35
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Stockage:Powder -20°C, 3 years , 4°C, 2 years
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
NSC 80467 has a similar spectrum of activity against the NCI-60 cell line panel, suppresses survivin expression, shows COMPARE correlation with DNA damaging agents, preferentially inhibits DNA synthesis, and induces a DNA damage response characterized by enhanced γH2AX and pKAP1 at concentrations lower than those capable of inhibiting survivin expression[1].
NSC 80467 (200 or 800 nM; 24 hours) inhibits surviving[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC3 cells
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Concentration:200 or 800 nM
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Incubation Time:24 hours
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Result:Associated with inhibition of survivin expression.
Chemical Information
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CAS No. 101982-51-8
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Appearance Solid
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Masse moléculaire 512.35
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Formule C24H22BrN3O5
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Color Gray to brown
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SMILES
O=C(C1=C2[N+](CC(C3=CC=C([N+]([O-])=O)C=C3)=O)=C(C)N1CC(C)C)C4=C(C=CC=C4)C2=O.[Br-]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years * The compound is unstable in solutions, freshly prepared is recommended.
Solvant et solubilité
DMSO : 25 mg/mL (48.79 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9518 mL | 9.7590 mL | 19.5179 mL | 48.7948 mL |
| 5 mM | 0.3904 mL | 1.9518 mL | 3.9036 mL | 9.7590 mL | |
| 10 mM | 0.1952 mL | 0.9759 mL | 1.9518 mL | 4.8795 mL | |
| 15 mM | 0.1301 mL | 0.6506 mL | 1.3012 mL | 3.2530 mL | |
| 20 mM | 0.0976 mL | 0.4879 mL | 0.9759 mL | 2.4397 mL | |
| 25 mM | 0.0781 mL | 0.3904 mL | 0.7807 mL | 1.9518 mL | |
| 30 mM | 0.0651 mL | 0.3253 mL | 0.6506 mL | 1.6265 mL | |
| 40 mM | 0.0488 mL | 0.2440 mL | 0.4879 mL | 1.2199 mL |
NSC 80467 Related Classifications
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