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Obrindatamab

(Synonyms: MGD009)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Obrindatamab is a humanized anti-B7-H3/CD3 bispecific antibody. Obrindatamab binds to B7-H3 and CD3, thereby mediating redirected cytotoxic T-lymphocyte (CTL) activity against B7-H3-expressing cancer cells. Obrindatamab can be used in research of cancer.

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  • Pureté: 99.58%
  • CAS No.: 2069959-72-2
  • Masse moléculaire:109.06 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Obrindatamab
  • Experimental Validation Results for Obrindatamab
  • Experimental Validation Results for Obrindatamab
  • Experimental Validation Results for Obrindatamab
  • Obrindatamab Chemical Structure
    Obrindatamab Chemical Structure
CAS No.: 2069959-72-2
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[email protected] [email protected]
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  • 1/16

    scFv-h-CH2-CH3(_scFv)_h-CH2-CH3

  • 1/16

    Immobilized Obrindatamab can bind Human CD3 epsilon/CD3e Protein (ECD, His Tag). The EC50 for this effect is 0.543 ng/mL.

  • 1/16

    Immobilized Obrindatamab can bind Human B7-H3 Protein (ECD, His Tag). The EC50 for this effect is 3.27 ng/mL.

  • 1/16

    Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Obrindatamab (HY-P99762). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.

  • Obrindatamab Chemical Structure
    1/16
  • Obrindatamab
  • Immobilized Obrindatamab can bind Human CD3 epsilon/CD3e Protein (ECD, His Tag). The EC50 for this effect is 0.543 ng/mL.
  • Immobilized Obrindatamab can bind Human B7-H3 Protein (ECD, His Tag). The EC50 for this effect is 3.27 ng/mL.
  • Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Obrindatamab (HY-P99762). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.
  • scFv-h-CH2-CH3(_scFv)_h-CH2-CH3