1. Immunology/Inflammation
  2. CD3
  3. Obrindatamab

Obrindatamab  (Synonyms: MGD009)

Cat. No.: HY-P99762 Purity: 99.58%
COA

Obrindatamab is a humanized anti-B7-H3/CD3 bispecific antibody. Obrindatamab binds to B7-H3 and CD3, thereby mediating redirected cytotoxic T-lymphocyte (CTL) activity against B7-H3-expressing cancer cells. Obrindatamab can be used in research of cancer.

For research use only. We do not sell to patients.

Obrindatamab Chemical Structure

Obrindatamab Chemical Structure

CAS No. : 2069959-72-2

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Based on 1 publication(s) in Google Scholar

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Description

Obrindatamab is a humanized anti-B7-H3/CD3 bispecific antibody. Obrindatamab binds to B7-H3 and CD3, thereby mediating redirected cytotoxic T-lymphocyte (CTL) activity against B7-H3-expressing cancer cells. Obrindatamab can be used in research of cancer[1].

In Vitro

MGD009 (MGD009) binds human and cynomolgus monkey CD3 and B7-H3 with KD values of 13.9, 14.7, 24.6, and 30.2 nM for human CD3ε/δ, cynomolgus CD3ε/δ, human B7-H3-His, and cynomolgus B7-H3-His, respectively[1].
Obrindatamab (0.01-1000 ng/mL; A498, U87, 22Rv1, and Detroit562 cells) mediates redirected killing of multiple B7-H3-expressing tumor lines[1].
Obrindatamab (0.01-1000 ng/mL; PBMCs and A498 cells) mediated T-cell activation and proliferation is target antigen dependent[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Obrindatamab (MGD009; 0.004-1 mg/kg; i.v.) inhibits growth and tumor regression of B7-H3-expressing tumor xenografts in human T cell or PBMC-reconstituted mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD/SCID mice with Co-mix mouse xenograft model, Established tumor model in human T-cell reconstituted NSG b2m-/- mice, Established tumor model in human T-cell reconstituted MHC1-/- mice[1]
Dosage: 0.004-1 mg/kg
Administration: intravenous injection
Result: Had antitumor activity in multiple in vivo models.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Obrindatamab]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 99.58%

References
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Obrindatamab Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Obrindatamab
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