Oxprenolol
Based on 1 publication(s) in Google Scholar
Oxprenolol (Ba 39089 free base) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle.
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- CAS No.: 6452-71-7
- Formule: C15H23NO3
- Masse moléculaire:265.35
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Oxprenolol
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Activité biologique
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β-adrenoceptor 7.1 nM (Ki) |
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Cell Line
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Type | Value | Description | References |
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| HEK293 | IC50 |
28.6 μM
Compound: oxprenolol
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Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy
Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy
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[PMID: 18788725] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male rats (230 to 300 g body wt) of the Wistar strain[2]
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Dosage:200 mg/kg
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Administration:Administered orally; daily for 3 weeks
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Result:This dosage produced effective beta-blockade.
Chemical Information
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CAS No. 6452-71-7
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Masse moléculaire 265.35
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Formule C15H23NO3
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SMILES
OC(COC1=CC=CC=C1OCC=C)CNC(C)C
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Synonyms
Ba 39089 free base
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Pharm Biomed Anal
Screening method of mildronate and over 300 doping agents by reversed-phase liquid chromatography-high resolution mass spectrometry. [Abstract]2021 Feb 20:195:113870. PMID: 33453569
Pureté et documentation
Références
[1]. T Nagatomo, et al. Binding Characteristics of 3H-dihydroalprenolol to Beta-Adrenoceptors of Rat Heart Treated With Neuraminidase. Jpn J Pharmacol. 1983 Aug;33(4):851-7. [Content Brief]
[2]. A S Manning, et al. Abrupt Withdrawal of Chronic Beta-Blockade: Adaptive Changes in Cyclic AMP and Contractility. J Mol Cell Cardiol. 1981 Nov;13(11):999-1009. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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