P1D-34
Based on 1 publication(s) in Google Scholar
P1D-34 is a Pin1 PROTAC degrader with a DC50 value of 177 nM. P1D-34 also down-regulates Pin1 client proteins such as Cyclin D1, Rb, Mcl-1, Akt, and c-Myc. P1D-34 shows anti-proliferative activities in a panel of acute myeloid leukemia (AML) cell lines. P1D-34 induces cell DNA damage and apoptosis by releasing ROS generation. Pink: PIN1 ligand (HY-171442A), Blue: CRBN ligand (HY-14658), Black: Linker (HY-W014883).
(Pink: PIN1 ligand (HY-171442A); Blue: Cereblon ligand (HY-14658); Black: linker (HY-W014883)).
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- Formule: C40H59ClN6O9S
- Masse moléculaire:835.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) P1D-34
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Activité biologique
Chemical Information
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Masse moléculaire 835.45
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Formule C40H59ClN6O9S
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SMILES
O=C(NCC(C)(C)CN([C@H](CC1)CS1(=O)=O)C(CCl)=O)CCC(NCCCCCCCCCCCCNC2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3=O)=O)C=C2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Pharmaceutics
Systematic Optimization of Proteolysis-Targeting Chimeras for PIN1 Enables Selective Degradation and Antitumor Activity In Vivo. [Abstract]2026 Feb 26;18(3):288. PMID: 41900774
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
P1D-34 Related Classifications
HY-171334A Related Classifications
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