country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-114797

Copy Link Print Information

PDE5-IN-16

PDE5-IN-16 is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC₅₀ of 0.8 nM. PDE5-IN-16 enhances the relaxation of corpus cavernosum tissue strips. PDE5-IN-16 is applicable for the research of erectile dysfunction.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 261769-44-2
Formule: C₂₃H₂₃ClN₆O₂
Masse moléculaire:450.93

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PDE5-IN-16 Chemical Structure

CAS No.: 261769-44-2

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Phosphodiesterase (PDE) :

In Vitro

PDE5-IN-16 (Compound 5) potently inhibits human platelet PDE5 with an IC₅₀ of 0.8 nM and exhibits high selectivity over bovine heart PDE1, rat kidney PDE2, human platelet PDE3, rat kidney PDE4, and bovine retina PDE6^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Parmacokinetics

Species	Dose	Route	Bioavailability	T_1/2
Rat^[1]	21 μmol/Kg	p.o.	33 %	1.2 h
Dog^[1]	23 μmol/Kg	p.o.	66 %	2.3 h

In Vivo

PDE5-IN-16 (Compound 5) (10-250 mg/kg; p.o.) shows no drug-related adverse effects in Rattus norvegicus at oral doses up to 50 mg/kg, with only mild body weight reduction in male rats at 250 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 261769-44-2
Masse moléculaire 450.93
Formule C₂₃H₂₃ClN₆O₂
SMILES

O=C(NCC=1C=CN=CC1)C2=CN=C3C(C=NN3CC)=C2NCC4=CC=C(OC)C(Cl)=C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Yu G, et al. Substituted pyrazolopyridines as potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction. J Med Chem. 2001 Mar 29;44(7):1025-7.
[Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis