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Cat. No.: HY-108327

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PF-05020182

PF-05020182 is an orally active opener for Kv7 channel, that activates human Kv7.2/7.3, Kv7.4 and Kv7.3/7.5 with EC₅₀ of 334, 625 and 588 nM, respectively. PF-05020182 exhibits anticonvulsant activity in rats corneal electric shock-induced tonic seizure (MES) models. PF-05020182 is blood-brain barrier (BBB) penetrable.

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CAS No.: 1354712-92-7
Formule: C₁₈H₃₀N₄O₄
Masse moléculaire:366.46

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PF-05020182 Chemical Structure

CAS No.: 1354712-92-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	EC₅₀	1327 nM Compound: 2, PF-05020182	Activation of rat Kv7.3/7.5 expressed in CHOK1 cells Activation of rat Kv7.3/7.5 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	294 nM Compound: 2, PF-05020182	Activation of rat Kv7.2/7.3 expressed in CHOK1 cells Activation of rat Kv7.2/7.3 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	334 nM Compound: 2, PF-05020182	Activation of human Kv7.2/7.3 expressed in CHOK1 cells Activation of human Kv7.2/7.3 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	376 nM Compound: 2, PF-05020182	Activation of rat Kv7.4 expressed in CHOK1 cells Activation of rat Kv7.4 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	588 nM Compound: 2, PF-05020182	Activation of human Kv7.3/7.5 expressed in CHOK1 cells Activation of human Kv7.3/7.5 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	625 nM Compound: 2, PF-05020182	Activation of human Kv7.4 expressed in CHOK1 cells Activation of human Kv7.4 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	>100000 nM Compound: 2, PF-05020182	Activation of human Kv7.1/KCNE1 expressed in CHOK1 cells Activation of human Kv7.1/KCNE1 expressed in CHOK1 cells	[PMID: 25987375]

Chemical Information

CAS No. 1354712-92-7
Masse moléculaire 366.46
Formule C₁₈H₃₀N₄O₄
SMILES

O=C(CC(C)(C)C)NC1=C(OC)N=C(N2CCC(CC2)OC)N=C1OC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Davoren JE, et al., Discovery of a novel Kv7 channel opener as a treatment for epilepsy. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4941-4944. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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