PhosTAC7
Based on 4 publication(s) in Google Scholar
PhosTAC7 is a heterobifunctional molecule named as a Phosphorylation Targeting Chimera (PhosTAC). PhosTAC7 can dephosphorylate the PDCD4 protein, FOXO3a protein, and tau protein by recruiting serine/threonine protein phosphatase 2A (PP2A). PhosTAC7 offers the advantage of selectively modulating the phosphorylation state of individual target proteins, making it a promising tool for research in cancer and tau protein-related neurodegenerative diseases (Alzheimer's disease).
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- Pureté: 99.23%
- CAS No.: 3016307-75-5
- Formule: C58H87ClN2O17
- Masse moléculaire:1119.77
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Stockage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) PhosTAC7
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Activité biologique
PhosTAC7 (1-5 μM, 24 h) mediates ternary complex formation between Halo-PDCD4/tau and FKBP12(F36V)-PP2A A in HeLa cells[1][2].
PhosTAC7 (0.25-10 μM, 2-24 h) effectively induces the dephosphorylation of PDCD4/tau, and can simultaneously regulate multiple phosphorylation sites, with dose and time dependence in Hela cells[1][2].
PhosTAC7 (5-10 μM, 3-8 h) alters the phosphorylation kinetics of FOXO3a and resists the stimulation of growth factors depending on the activity of the PP2A phosphatase in Hela cells[1].
PhosTAC7 (0.5 μM, 24 h+ washout 24-48 h) still maintains a significant dephosphorylation effect even after the replacement of the fresh culture medium in Hela cells[2].
PhosTAC7 (1 μM, 1-3 d) indirectly accelerates tau degradation by promoting dephosphorylation in Hela cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Wild-type HeLa cells and Halo-PDCD4/ FKBP12(F36V)-PP2A A P179R-mutant HeLa cells
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Concentration:1, 5 and 10 μM
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Incubation Time:2, 4, 8, 12, 16 and 24 h
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Result:Dose and time-dependently induced dephosphorylation at the Ser67 site of PDCD4 in wild cells.
Completely lost its ability to phosphorylate in the P179R mutant cell line.
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Cell Line:Wild-type HeLa cells
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Concentration:5 μM
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Incubation Time:Pretreated 3 h and stimulated by EGF for 0, 30, 60, 120, 180 and 300 min
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Result:Maintained the basal phosphorylation level and resisted EGF stimulation.
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Cell Line:HeLa cells
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Concentration:0.25, 0.5, 1 and 10 μM
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Incubation Time:24 h
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Result:Effectively and specifically induced Tau dephosphorylation, and depended on the functional PP2A holoenzyme.
Chemical Information
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CAS No. 3016307-75-5
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Appearance Oil
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Masse moléculaire 1119.77
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Formule C58H87ClN2O17
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Color Colorless to light yellow
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SMILES
CC[C@@H](C1=CC(OC)=C(C(OC)=C1)OC)C(N2CCCC[C@H]2C(O[C@@H](C3=CC(OCC(NCCOCCOCCOCCOCCOCCOCCOCCCCCCCl)=O)=CC=C3)CCC4=CC(OC)=C(C=C4)OC)=O)=O
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Synonyms
OGTAC-3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (4)
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Journal Impact Factor
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Most Recent
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Phytomedicine
2025 May:140:156619. PMID: 40088745 -
Cell Genom
Pooled endogenous protein tagging and recruitment for systematic profiling of protein function. [Abstract]2024 Sep 4:100651. PMID: 39255790 -
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Solvant et solubilité
DMSO : 100 mg/mL (89.30 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (272 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8930 mL | 4.4652 mL | 8.9304 mL | 22.3260 mL |
| 5 mM | 0.1786 mL | 0.8930 mL | 1.7861 mL | 4.4652 mL | |
| 10 mM | 0.0893 mL | 0.4465 mL | 0.8930 mL | 2.2326 mL | |
| 15 mM | 0.0595 mL | 0.2977 mL | 0.5954 mL | 1.4884 mL | |
| 20 mM | 0.0447 mL | 0.2233 mL | 0.4465 mL | 1.1163 mL | |
| 25 mM | 0.0357 mL | 0.1786 mL | 0.3572 mL | 0.8930 mL | |
| 30 mM | 0.0298 mL | 0.1488 mL | 0.2977 mL | 0.7442 mL | |
| 40 mM | 0.0223 mL | 0.1116 mL | 0.2233 mL | 0.5582 mL | |
| 50 mM | 0.0179 mL | 0.0893 mL | 0.1786 mL | 0.4465 mL | |
| 60 mM | 0.0149 mL | 0.0744 mL | 0.1488 mL | 0.3721 mL | |
| 80 mM | 0.0112 mL | 0.0558 mL | 0.1116 mL | 0.2791 mL |
PhosTAC7 Related Classifications
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