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Cat. No.: HY-187648

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pNPPT cyclohexanamine

Name: pNPPT cyclohexanamine
Brand: MedChemExpress
SKU: HY-187648
Availability: PreOrder

(Synonyms: p-Nitrophenyl phosphorothioate cyclohexanamine)

pNPPT cyclohexanamine (p-Nitrophenyl phosphorothioate cyclohexanamine) is a dianionic aryl thiophosphate monoester substrate of PP1γ (protein phosphatase 1γ). PP1γ catalyzes the hydrolysis of pNPPT cyclohexanamine.

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CAS No.: 167698-72-8
Formule: C₁₈H₃₂N₃O₅PS
Masse moléculaire:433.50

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

pNPPT cyclohexanamine Chemical Structure

CAS No.: 167698-72-8

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
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Activité biologique

Description

In Vitro

pNPPT (compound 2a) cyclohexanamine is efficiently hydrolyzed by wild-type PP1γ, with a maximum catalytic efficiency of 31 M^-1s^-1 and a second-order rate acceleration ratio of 1.7 × 10¹¹. The transition state is characterized by restricted leaving group bond cleavage and effective general acid neutralization of the leaving group. The hydrolysis catalytic efficiency decreases for the PP1 R96K and PP1 R221K single mutants of PP1γ, with corresponding catalytic efficiency values of 0.8 M^-1s^-1 and 1.9 M^-1s^-1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 167698-72-8
Masse moléculaire 433.50
Formule C₁₈H₃₂N₃O₅PS
SMILES

O=P(O)(S)OC(C=C1)=CC=C1[N+]([O-])=O.NC2CCCCC2.NC3CCCCC3
Synonyms

p-Nitrophenyl phosphorothioate cyclohexanamine
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Chu Y, et al. Transition States and Control of Substrate Preference in the Promiscuous Phosphatase PP1. Biochemistry, 2017, 56(30): 3923-3933.

Calculators

Calculateur de molarité

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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