Polycarbophil
Based on 1 Customer Validation
Polycarbophil is an orally active hydrophilic polymer. Polycarbophil achieves bioadhesion through hydrogen bonding between carboxyl groups and mucosal surfaces, and prolongs compound retention time and regulates compound release through swelling properties. Polycarbophil relieves constipation and diarrhea.
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- CAS No.: 9003-97-8
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Polycarbophil (0.5%-1.0% w/v; 25-120 min) increases the apparent permeability of Pipemidic acid (HY-B1210) by 2.3-4.3 times in isolated porcine urinary bladder wall, primarily due to enhanced urothelium permeability[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Polycarbophil (500-1000 mg/kg; p.o.; before constipation inducer) restores fecal weight and relieves constipation in Loperamide (HY-156131)/Clonidine (HY-12721)-induced constipated rats[3].
Polycarbophil (500-1000 mg/kg; p.o.; before stress) reduces stress-induced fecal output in wrap restraint stress (WRS)-induced defecation rats[3].
Polycarbophil (500-1000 mg/kg; p.o.; before diarrhea inducer) suppresses Castor oil (HY-107799)-induced diarrhea in rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 9003-97-8
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Appearance Solid
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Color White to off-white
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SMILES
[Polycarbophil]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[2]. Grabnar I, et al. Influence of chitosan and polycarbophil on permeation of a model hydrophilic drug into the urinary bladder wall. Int J Pharm. 2003 Apr 30;256(1-2):167-73. [Content Brief]
[3]. Saito T, et al. Laxative and anti-diarrheal activity of polycarbophil in mice and rats. Jpn J Pharmacol. 2002 Jun;89(2):133-41. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Polycarbophil Related Classifications
HY-154659 Related Classifications
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