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Cat. No.: HY-79584

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Propargyl-Tos

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Propargyl-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-Tos is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Pureté: 98.74%
CAS No.: 23418-85-1
Formule: C₁₁H₁₂O₃S
Masse moléculaire:224.28

Stockage:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Propargyl-Tos Chemical Structure

CAS No.: 23418-85-1

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Propargyl-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. Propargyl-Tos is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

Cleavable Linker

Voir tous les produits spécifiques à Isoform ADC Linkers :

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 23418-85-1
Appearance Liquid (Density: 1.27 g/cm³)
Masse moléculaire 224.28
Formule C₁₁H₁₂O₃S
Color Colorless to light yellow
SMILES

C#CCCOS(C1=CC=C(C)C=C1)(=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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Propargyl-Tos

Covalent Screening Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Alkyne Compound Library

Covalent Fragment Library

Tyrosine Focused Covalent Fragment Library

Lysine Focused Covalent Fragment Library

Multifunctional Covalent Fragment Library

Anti-Cancer Compound Library

Voir tous les produits spécifiques à Isoform ADC Linkers

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Propargyl-Tos

Covalent Screening Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Alkyne Compound Library

Covalent Fragment Library

Tyrosine Focused Covalent Fragment Library

Lysine Focused Covalent Fragment Library

Multifunctional Covalent Fragment Library

Anti-Cancer Compound Library

Voir tous les produits spécifiques à Isoform ADC Linkers

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Propargyl-Tos Related Classifications

HY-79584 Related Classifications