CD1b
CD1b specializes in presenting large microbial lipids from mycobacteria, including mycolic acid, glucose monomycolate and lipoarabinomannan, to alpha-beta T cell receptors. Its antigen-binding architecture is unique among CD1 isoforms, combining C', G' and T' hydrophobic tunnels that accommodate the longest lipid tails presented by any antigen-presenting molecule. Expression is restricted to professional antigen-presenting cells such as dendritic cells and is transcriptionally induced during inflammation and infection. CD1b-restricted responses against Mycobacterium tuberculosis antigens have made it a focus of tuberculosis vaccine design, and structural studies of its tunnels continue to guide lipid-antigen discovery.
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CD1b Protéines Recombinantes (2)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
