PYRIB-SO 2
PYRIB-SO 2 is a potent antimitotic agent. PYRIB-SO 2 shows antiproliferative activity and induces cell cycle arrest at G2/M phase. PYRIB-SO 2 reduces and disruptes microtubule structures. PYRIB-SO 2 binds to the colchicine-binding site (C-BS) of α, β-tubulin.
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- Formule: C14H12ClN3O4S
- Masse moléculaire:353.78
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HaCaT | IC50 |
17 nM
Compound: 2
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Antiproliferative activity against human HaCaT cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
Antiproliferative activity against human HaCaT cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
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[PMID: 38614151] |
| MCF7 | IC50 |
50 nM
Compound: 2
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
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[PMID: 38614151] |
| MDA-MB-231 | IC50 |
220 nM
Compound: 2
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
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[PMID: 38614151] |
| MDA-MB-468 | IC50 |
9 nM
Compound: 2
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Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
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[PMID: 38614151] |
PYRIB-SO 2 (150 nM; 24 h) induces cell cycle arrest at G2/M phase [1].
PYRIB-SO 2 (138 nM; 24 h) reduces and disruptes microtubule structures in MCF7 cells [1].
PYRIB-SO 2 (5, 50 µM) reduces the formation of the EBI:β-tubulin adduct [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF7, MDA-MB-468, MDA-MB-231 cells
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Concentration:0-500 nM
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Incubation Time:48 h
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Result:Showed antiproliferative activity with IC50s of 50, 9, 220 nM for MCF7, MDA-MB-468 and MDA-MB-231 cells, respectively.
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Cell Line:MCF7 cells
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Concentration:150 nM
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Incubation Time:24 h
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Result:Iduced cell cycle arrest at G2/M phase with the percentage of 77%.
Chemical Information
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Masse moléculaire 353.78
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Formule C14H12ClN3O4S
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SMILES
ClC1=CC(OS(=O)(C2=CC=C(C=C2)N3CCNC3=O)=O)=CN=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PYRIB-SO 2 Related Classifications
HY-163523 Related Classifications
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