Remdesivir-d5
Based on 2 publication(s) in Google Scholar
Remdesivir-d5 (GS-5734-d5) is a deuterium labeled Remdesivir (HY-104077). Remdesivir (GS-5734) is a nucleoside analogue with effective antiviral activity. Remdesivir can inhibit the synthesis of viral DNA or RNA. Remdesivir can be used for the research of infection, such as SARS-CoV and MHV infection.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 99.86%
- CAS No.: 2440242-47-5
- Formule: C27H30D5N6O8P
- Masse moléculaire:607.61
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Remdesivir-d5
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Activité biologique
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2440242-47-5
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Unlabeled CAS 1809249-37-3
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Appearance Solid
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Masse moléculaire 607.61
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Formule C27H30D5N6O8P
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Color White to off-white
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SMILES
C[C@H](N[P@@](OC1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])(OC[C@H]2O[C@@](C#N)(C3=CC=C4C(N)=NC=NN43)[C@H](O)[C@@H]2O)=O)C(OCC(CC)CC)=O
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Synonyms
GS-5734-d5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Clin Transl Sci
Exploration for the effect of renal function and renal replacement therapy on pharmacokinetics of remdesivir and GS-441524 in patients with COVID-19: A limited case series. [Abstract]2022 Mar;15(3):732-740. PMID: 34761554 -
J Mass Spectrom Adv Clin Lab
Development and validation of a paper spray mass spectrometry method for the rapid quantitation of remdesivir and its active metabolite, GS-441524, in human plasma. [Abstract]2022 Aug:25:27-35. PMID: 35721272
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (164.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (286 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9(2). pii: e00221-18. [Content Brief]
[2]. Wang M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. [Content Brief]
[3]. Hu H, et al. Optimization of the Prodrug Moiety of Remdesivir to Improve Lung Exposure/Selectivity and Enhance Anti-SARS-CoV-2 Activity. J Med Chem. 2022 Sep 22;65(18):12044-12054. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.6458 mL | 8.2290 mL | 16.4579 mL | 41.1448 mL |
| 5 mM | 0.3292 mL | 1.6458 mL | 3.2916 mL | 8.2290 mL | |
| 10 mM | 0.1646 mL | 0.8229 mL | 1.6458 mL | 4.1145 mL | |
| 15 mM | 0.1097 mL | 0.5486 mL | 1.0972 mL | 2.7430 mL | |
| 20 mM | 0.0823 mL | 0.4114 mL | 0.8229 mL | 2.0572 mL | |
| 25 mM | 0.0658 mL | 0.3292 mL | 0.6583 mL | 1.6458 mL | |
| 30 mM | 0.0549 mL | 0.2743 mL | 0.5486 mL | 1.3715 mL | |
| 40 mM | 0.0411 mL | 0.2057 mL | 0.4114 mL | 1.0286 mL | |
| 50 mM | 0.0329 mL | 0.1646 mL | 0.3292 mL | 0.8229 mL | |
| 60 mM | 0.0274 mL | 0.1371 mL | 0.2743 mL | 0.6857 mL | |
| 80 mM | 0.0206 mL | 0.1029 mL | 0.2057 mL | 0.5143 mL | |
| 100 mM | 0.0165 mL | 0.0823 mL | 0.1646 mL | 0.4114 mL |
Remdesivir-d5 Related Classifications
HY-104077S Related Classifications
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