RX 336M
RX 336M is a dihydrocodeinone analogue. RX 336M induces behaviors consisting of consisting of behavioral activation, rapid forepaw movements, excessive grooming, and whole body "wet-dog" shakes (WDS) (rapid twisting of the head and trunk with the forepaws leaving the ground). RX 336M can be used for the study of neurological disease.
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- CAS No.: 6701-66-2
- Formule: C24H29NO3
- Masse moléculaire:379.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague Dawley rats (weight ranges: 80-90 g, 120-140 g, 190-210 g, 280-300 g)[1]
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Dosage:1.5, 3, 6, 12 mg/kg
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Administration:i.p. for a single dose
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Result:Induced grooming behavior that primarily involved face washing and preening of the flanks with the mouth or forepaws, with very little hindpaw scratching.
Caused a sequential behavioral pattern in rats: shaking first, followed by face washing, then grooming of the flanks, and repetition of this sequence.
Led to a decrease in the correlation between the number of "wet-dog" shakes (WDS) and the percentage of maximum possible grooming episodes (%MGE).
Showed improved correlation between WDS and %MGE in rats weighing 190-210 g and 280-300 g.
Increased the number of WDS but decreased the correlation between WDS and grooming when the dose was doubled to 12 mg/kg in large rats.
Resulted in a decline in %MGE but an improvement in the correlation between shaking and grooming.
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Animal Model:Male and female Long-Evans rats of different ages (21 days, 30 days, 39 days, and 48 days old)[2]
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Dosage:6 mg/kg
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Administration:i.p. for a single dose
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Result:Induced more significant excessive grooming in younger rats than in older ones, with gender differences.
Caused age- and sex-related differences in the frequency of "wet-dog" shakes (WDS).
Had no significant effect on the activity levels (rearing and locomotion) of rats, while female rats generally had higher activity levels than males.
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Animal Model:39-day-old female Long-Evans rats received daily subcutaneous injections of testosterone benzoate (1 mg/kg/day) for 8 consecutive days starting from 32 days old[2]
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Dosage:6 mg/kg
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Administration:i.p. for a single dose
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Result:Enhanced the responses of female rats to excessive grooming and "wet-dog" shakes.
Had no significant behavioral effects in 39-day-old female rats pretreated with oil vehicle.
Chemical Information
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CAS No. 6701-66-2
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Masse moléculaire 379.49
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Formule C24H29NO3
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SMILES
O=C1C2OC3=C(C=CC(CC4C5(C6C1)CCC(C)=C6C)=C3C25CCN4C)OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Lee EJ, et al. Discovery of a Novel Potent EGFR Inhibitor Against EGFR Activating Mutations and On-Target Resistance in NSCLC. Clin Cancer Res. 2024 Apr 15;30(8):1582-1594. [Content Brief]
[2]. Isaacson RL, et al. Age- and sex-related induction of excessive grooming and "wet-dog" shakes by the codeinone RX 336-M in the rat. Behav Neural Biol. 1987 May;47(3):250-61. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RX 336M Related Classifications
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