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Sacituzumab

(Synonyms: HRS7; hRS7)
9 Cited Publications
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Based on 9 publication(s) in Google Scholar

Sacituzumab is a humanized IgG1 monoclonal antibody targeting Trophoblast cell surface antigen 2 (TROP2). Sacituzumab demonstrates a lack of antitumor effects alone and does not inhibit the function of TROP-2 during tumor metastasis, binding to the linear epitopes of TROP-2 protein. Sacituzumab can be used for the synthesis of antibody-drug conjugates (ADC) drug Sacituzumab govitecan (HY-132254). Sacituzumab govitecan can be used in the field of triple-negative breast cancer.

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  • Pureté: 99.9%
  • CAS No.: 1796566-95-4
  • Masse moléculaire:145.52 kDa
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Sacituzumab
  • Experimental Validation Results for Sacituzumab
  • Experimental Validation Results for Sacituzumab
  • Experimental Validation Results for Sacituzumab
  • Sacituzumab Chemical Structure
    Sacituzumab Chemical Structure
CAS No.: 1796566-95-4
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Loaded Sacituzumab on AHC2 biosensor, can bind TROP-2 Protein, Human (248a.a, HEK293, His, HY-P70457) with an affinity constant of 8.077E-10 M as determined in BLI assay.

  • 1/16

    Flow cytometry analysis of Trop2 overexpression HEK293 cells labelling Trop2 with Sacituzumab at 67nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).

  • 1/16

    Immobilized TROP-2 Protein, Human (HY-P70457) can bind Sacituzumab, with the EC50 is 1.335 ng/mL.

  • Sacituzumab Chemical Structure
    1/16
  • Sacituzumab
  • Loaded Sacituzumab on AHC2 biosensor, can bind TROP-2 Protein, Human (248a.a, HEK293, His, HY-P70457) with an affinity constant of 8.077E-10 M as determined in BLI assay.
  • Flow cytometry analysis of Trop2 overexpression HEK293 cells labelling Trop2 with Sacituzumab at 67nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
  • Immobilized TROP-2 Protein, Human (HY-P70457) can bind Sacituzumab, with the EC50 is 1.335 ng/mL.