TACSTD2 - tumor associated calcium signal transducer 2 Gene

Also Known as EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 4070

About TACSTD2

Cytogenetic location: 1p32.1 Genomic coordinates (GRCh38): 1:58,575,433-58,577,252 (from NCBI)

This gene has 1 transcript (splice variant), 194 orthologues, 1 paralogue and is associated with 3 phenotypes.

Summary

This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]

TACSTD2 Products (1)

mRNA Protein Name
NM_002353.3 NP_002344.2 tumor-associated calcium signal transducer 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
15607035 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TACSTD2 Protein Structure

Thyroglobulin_1

Thyroglobulin_1: Thyroglobulin type-1 repeat (73 - 145)

  • 0
  • 100
  • 200
  • 300
  • 323 a.a.
Protein Preferred Names Protein Names

tumor-associated calcium signal transducer 2

  • 40kD glycoprotein, identified by monoclonal antibody GA733

TACSTD2 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
TACSTD2 P09758 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
Intra
TACSTD2 P09758 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
TACSTD2 P09758 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
TACSTD2 P09758 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
TACSTD2 P09758 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
TACSTD2 P09758 KRTAP5-2 Homo sapiens Q701N4
Y2H Prey Pooling
32296183
Intra
TACSTD2 P09758 KRTAP5-2 Homo sapiens Q701N4
Validated Y2H
32296183
Intra
TACSTD2 P09758 KRTAP5-2 Homo sapiens Q701N4
Y2H Array
32296183
Intra
TACSTD2 P09758 LCE2C Homo sapiens Q5TA81
Y2H Array
32296183
Intra
TACSTD2 P09758 LCE2C Homo sapiens Q5TA81
Validated Y2H
32296183
Intra
TACSTD2 P09758 LCE2C Homo sapiens Q5TA81
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TACSTD2 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P70457 TROP-2 Protein, Human (248a.a, HEK293, His) P09758 (H27-T274) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70770 TROP-2 Protein, Human (HEK293, His-Avi) P09758 (H27-T274) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70728 TROP-2 Protein, Human (187a.a, HEK293, His) P09758 (T88-T274) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P71095 TROP-2 Protein, Human (187a.a, HEK293, Fc) P09758 (T88-T274) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72015 TROP-2 Protein, Human (HEK293, hFc) P09758 (H27-T274) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74490 TROP-2 Protein, Human (HEK293, His-hFc) P09758 (H27-T274) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78223 TROP-2 Protein, Human (Biotinylated, HEK293, His-Avi) P09758 (H27-T274) ≥ 95%, as determined by Bis-Tris PAGE.

TACSTD2 抗体

製品番号 製品名 アプリケーション 反応性
HY-P81751 TROP2 Antibody (YA1496) WB, IHC-P, FC, ELISA Human
HY-P82385 TROP2 Antibody (YA2130) WB, IHC-P, IHC-F, ICC/IF Human, Mouse, Rat
HY-P82385A TROP2 Antibody (YA2130) (PBS only) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat
HY-P86704 TROP2 Antibody (YA6396) IHC-P, IHC-F, IF-Tissue Human

関連疾患

Diseases Alias
Corneal Dystrophy, Gelatinous Drop-Like

  • Gelatinous Drop-Like Corneal Dystrophy

  • GDLD

  • Cdgdl

  • Corneal Amyloidosis

  • Lattice Corneal Dystrophy Type Iii

  • Amyloidosis, Corneal

  • Amyloid Corneal Dystrophy, Japanese Type

  • Gdcd

  • Primary Familial Amyloidosis Of The Cornea

  • Subepithelial Amyloidosis Of The Cornea

  • Corneal Dystrophy, Lattice Type 3

  • Corneal Dystrophy, Lattice Type Iii

  • Lattice Corneal Dystrophy, Type Iii

  • Amyloidosis Corneal

  • Lattice Corneal Dystrophy Type3

  • Amyloid Corneal Dystrophy Japanese Type

  • Dystrophy, Corneal, Gelatinous Drop-Like

  • Amyloid Of Cornea
Lattice Corneal Dystrophy

  • Familial Amyloid Neuropathy, Finnish Type

  • Familial Amyloid Polyneuropathy, Type V
Corneal Dystrophy
Epithelial And Subepithelial Dystrophy
Taeniasis

  • Beef Tapeworm Infection

  • Infection By Taeniarhynchus Saginatus

  • Taenia Saginata Infectious Disease

  • Taenia Saginata Infection

  • Pork Tapeworm Infection

  • Armed Tapeworm Infection

  • Infection By Taenia Solium

  • Intestinal Taenia Solium Infection

  • Pork Tapeworm

  • Taenia Solium Taeniasis

  • Adult Pork Tapeworm Infection

  • Adult Pork Tapeworm

  • Beef Tapeworm

  • Infection By Taenia Saginata

  • Unarmed Tapeworm Infection

  • Taenia Saginata Taeniasis

  • Infection Due To Adult Tapeworm Taenia Saginata

  • Mediocanellata Taenia Infection

  • Infestation By Taenia Saginata

  • Infestation By Taenia Mediocanellata
Gastrointestinal Carcinoma

  • Gastrointestinal Neoplasms
Coenurosis

  • Coenuriasis
Ovary Leiomyosarcoma

  • Leiomyosarcoma Of Ovary
Corneal Dystrophy, Reis-Bucklers Type

  • Reis-Bucklers Corneal Dystrophy

  • Rbcd

  • CDRB

  • Cdb1

  • Corneal Dystrophy Of Bowman Layer Type I

  • Geographic Corneal Dystrophy

  • Granular Corneal Dystrophy Type Iii

  • Reis-Bucklers' Corneal Dystrophy

  • Anterior Limiting Membrane Dystrophy Type I

  • Corneal Dystrophy Of Bowman Layer Type 1

  • Corneal Dystrophy Of Bowman Layer, Type I

  • Corneal Dystrophy, Geographic

  • Granular Corneal Dystrophy, Type Iii

  • Corneal Dystrophy Reis Bucklers Type

  • Corneal Dystrophy Geographic

  • Reis Bucklers Corneal Dystrophy

  • Reis Bucklers Dystrophy

  • Anterior Limiting Membrane Dystrophy Type 1

  • Atypical Granular Corneal Dystrophy

  • Granular Corneal Dystrophy Type 3

  • Superficial Granular Corneal Dystrophy

  • Corneal Dystrophy Of Bowman Layer, Type 1

  • Dystrophy, Corneal, Reis-Bucklers Type
Corneal Dystrophy, Thiel-Behnke Type

  • Thiel-Behnke Corneal Dystrophy

  • Tbcd

  • CDTB

  • Cdb2

  • Corneal Dystrophy Of Bowman Layer Type Ii

  • Anterior Limiting Membrane Dystrophy Type Ii

  • Waardenburg-Jonker Corneal Dystrophy

  • Corneal Dystrophy Of Bowman Layer, Type Ii

  • Corneal Dystrophy, Honeycomb-Shaped

  • Corneal Dystrophy Honeycomb-Shaped

  • Corneal Dystrophy Thiel Behnke Type

  • Corneal Dystrophy Honeycomb Shaped

  • Corneal Dystrophy Of The Bowman Layer Type 2

  • Thiel Behnke Corneal Dystrophy

  • Anterior Limiting Membrane Dystrophy Type 2

  • Corneal Dystrophy Of Bowman Layer Type 2

  • Curly Fiber Corneal Dystrophy

  • Honeycomb Corneal Dystrophy

  • Honeycomb-Shaped Corneal Dystrophy

  • Dystrophy, Corneal, Thiel-Behnke Type
Cysticercosis

  • Neurocysticercosis

  • Submacular Cysticercosis

  • Intestinal Taenia Solium Infection

  • Pork Tapeworm Infection

  • Tapeworm Infection: Intestinal Taenia Solum

  • Tapeworm Infection: Pork

  • Tenia Solium Infectious Disease

  • Taeniasis

  • Tenia Solium Infection

  • Cysticerciasis Infection Due To Larval Form Of Taenia Solium
Ovarian Carcinosarcoma

  • Ovarian Malignant Mixed Mullerian Tumor

  • Mmmt Of The Ovary

  • Malignant Mixed Mullerian Tumor Of The Ovary

  • Ovarian Malignant Mixed Epithelial Mesenchymal Tumor

  • Ovarian Malignant Mesodermal Mixed Tumor

  • Ovarian Mmmt

  • Malignant Mixed Müllerian Tumor Of The Ovary

  • Ovarian Malignant Mixed Müllerian Tumor

  • Carcinosarcoma Of Ovary
Corneal Deposit

  • Deposits - Cornea
Granular Corneal Dystrophy

  • Granular Dystrophy Corneal

  • Corneal Dystrophies, Hereditary

  • Hereditary Corneal Dystrophy

  • Corneal Dystrophy Nos

  • Familial Hereditary Corneal Degeneration

  • Hereditary Corneal Opacity
Corneal Dystrophy, Avellino Type

  • Avellino Corneal Dystrophy

  • CDA

  • Combined Granular-Lattice Corneal Dystrophy

  • Cgd2

  • Granular Corneal Dystrophy Type 2

  • Acd

  • Granular Corneal Dystrophy 2

  • Corneal Dystrophy Avellino Type

  • Granular Corneal Dystrophy Type Ii

  • Granular Corneal Dystrophy, Type Ii

  • Combined Granular-Lattice Corneal Dystrophies

  • Granular And Lattice Corneal Dystrophies

  • Granular-Lattice Corneal Dystrophy

  • Gcd2

  • Gcdii

  • Granular-Lattice Corneal Dystrophy
Macular Dystrophy, Corneal

  • Macular Corneal Dystrophy

  • MCD

  • Corneal Dystrophy, Macular Type

  • Groenouw Type Ii Corneal Dystrophy

  • Fehr Corneal Dystrophy

  • Macular Dystrophy, Corneal Type 1

  • Mcdc1

  • Macular Corneal Dystrophy Type Ii

  • Macular Corneal Dystrophy, Type Ii

  • Macular Corneal Dystrophy, Type I

  • Mcdc1, Formerly

  • Macular Dystrophy, Corneal, 1

  • Macular Corneal Dystrophy Type 1

  • Corneal Dystrophy Groenouw Type Ii

  • Corneal Dystrophy Macular Type

  • Macular Corneal Dystrophy Type I

  • Dystrophy, Macular, Corneal
Premature Ovarian Failure 18

  • POF18

  • Primary Ovarian Insufficiency 18

  • Ovarian Failure, Premature, Type 18
Corneal Dystrophy, Band-Shaped

  • Band Keratopathy

  • Band-Shaped Keratopathy
Corneal Degeneration

  • Degenerative Corneal Opacity
Klatskin'S Tumor

  • Klatskin Tumor

  • Hilar Cholangiocarcinoma

  • Perihilar Cholangiocarcinoma

  • Hilar Cholangiocellular Carcinoma

  • Klatskin Tumour

  • Klatskin'S Tumour

  • Perihilar Extrahepatic Bile Duct Carcinoma

  • Hilar Cca

  • Adenocarcinoma Of Hepatic Duct

  • Klatskin Tumour Of Biliary Tree
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Epithelial-Stromal Tgfbi Dystrophy
Corneal Disease

  • Corneal Diseases

  • Corneal Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS14152 TACSTD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17390 Tacstd2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23845 Tacstd2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
阻害性抗体 (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P990827 Anti-TROP-2 Antibody (Pr1E11) Inhibitor 95.00% Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus TACSTD2 VGNC VGNC:35563
Felis catus TACSTD2 VGNC VGNC:80372
Mus musculus TACSTD2 MGD MGI:1861606
Macaca mulatta TACSTD2 VGNC VGNC:78085
Rattus norvegicus TACSTD2 RGD RGD:1359498
Others TACSTD2 NCBI