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Cat. No.: HY-149300

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SB-1436

SB-1436 is an Cholinesterase (ChE) inhibitor, inhibits acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and recombinant human acetylcholinesterase (rHuAChE) with IC₅₀s of 0.176, 0.37 and 0.08 μM, respectively. SB-1436 inhibits AChE and BChE in a non-competitive manner with K_is of 0.046 and 0.115 μM, respectively. SB-1436 significantly stops the self-aggregation of Aβ, and can be used for neurological disease research.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2925298-08-2
Formule: C₂₅H₂₁ClFNO
Masse moléculaire:405.89

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SB-1436 Chemical Structure

CAS No.: 2925298-08-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

EeAChE

0.176 μM (IC₅₀)

eqBCHE

0.37 μM (IC₅₀)

EeAChE

0.046 μM (Ki)

eqBCHE

0.115 μM (Ki)

Voir tous les produits spécifiques à Isoform Cholinesterase (ChE) :

AChE
BChE

In Vitro

SB-1436 (Compound 7av) (1 μM, 20 min) inhibits AChE, BChE and rHuAChE with IC₅₀s of 0.176, 0.37 and 0.08 μM, respectively^[1].
SB-1436 (0.78-100 μM, 48 hours) reduces the cell viability in J774A.1 and primary astrocytes cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

J774A.1 cells and primary astrocytes
Concentration:

0.78-100 μM
Incubation Time:

48 hours
Result:

Reduced the cell viability in J774A.1 and primary astrocytes cell lines, and its GI₅₀ in both cell types is ∼6.25 μM.

Chemical Information

CAS No. 2925298-08-2
Masse moléculaire 405.89
Formule C₂₅H₂₁ClFNO
SMILES

COC1=CC2=C(C=C(/C=C/C3=CC=[N+](CC4=CC=C(F)C=C4)C=C3)C=C2)C=C1.[Cl-]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Abdullaha M, et.al. Methoxy-naphthyl-Linked N-Benzyl Pyridinium Styryls as Dual Cholinesterase Inhibitors: Design, Synthesis, Biological Evaluation, and Structure-Activity Relationship. ACS Omega. 2023 May 9;8(20):17591-17608. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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SB-1436

Voir tous les produits spécifiques à Isoform Cholinesterase (ChE)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

SB-1436 Related Classifications

HY-149300 Related Classifications