SGP8
SGP8 (IAVPGEVA) is an octapeptide produced by hydrolysis of soybean 11S globulin, which has the effects of regulating lipid metabolism, inflammation and fibrosis. SGP8 (IAVPGEVA) exhibits inhibitory activity against DPP4 and inhibits the JNK-c-Jun signaling pathway, and has the ability to inhibit non-alcoholic steatohepatitis (NASH).
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- CAS No.: 855790-98-6
- Formule: C34H58N8O11
- Masse moléculaire:754.87
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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DPP-4 |
SGP8 (0,100 and 500 µM; 24 h) has regulatory effects on lipid metabolism, inflammation, and fibrosis [1].
SGP8 (0,100 and 500 µM; 24 h) increases significantly the serum GLP-1 content and targets DPP4 with an inhibitory activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:L02 cells
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Concentration:0,100 and 500 µM
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Incubation Time:24h
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Result:Improved the mRNA expression of lipid metabolism genes related to Cd36, Scd1, Cpt1 and Pparα and significantly reduced the mRNA expression of inflammatory genes Tnfα, Il-1β, and Ccl5.
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Cell Line:L02 cells
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Concentration:0,100 and 500 µM
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Incubation Time:24h
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Result:Reduced the expression of lipid metabolism genes related to CD36, FAS, and SREBP-1 compared to the 1 mM PO model group.
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Cell Line:LX2 cells
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Concentration:0 and 500 µM
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Incubation Time:24h
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Result:Reduced effectively TGFβ1-induced expression of α-SMA and Collagen I protein expression.
SGP8 (15 mg/kg, ip; everyday for eight weeks) mitigates HFD-induced hepatic injury and metabolic disorders in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Healthy 7-week-old male C57BL/6J mice (22 and 27 g)[1]
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Dosage:15 mg/kg; everydays for four weeks
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Administration:i.g.
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Result:Did not reverse the weight loss of mice caused by the MCD diet. Reduces the ratio of liver weight to body weight, as well as liver TG and TC content. Reduces the activities of ALT and AST in the serum of MCD dietinduced NASH mice. Improved liver fibrosis in MCD diet-induced NASH mice.
Chemical Information
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CAS No. 855790-98-6
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Masse moléculaire 754.87
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Formule C34H58N8O11
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Sequence
Ile-Ala-Val-Pro-Gly-Glu-Val-Ala
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Sequence Shortening
IAVPGEVA
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SGP8 Related Classifications
HY-P6177 Related Classifications
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