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Cat. No.: HY-122681

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SR-16434

(Synonyms: SR-16435 free base)

SR-16434 is a nociceptin/orphanin FQ (NOP)/μ-opioid receptor partial agonist, with high binding affinity (NOP receptor K_i=7.49; μ-Opioid receptor K_i=2.70). SR-16434 can relieve pain.

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CAS No.: 857262-16-9
Formule: C₂₂H₃₀N₂O
Masse moléculaire:338.49

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

SR-16434 Chemical Structure

CAS No.: 857262-16-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

NOP receptor

7.49 (Ki)

μ-opioid

2.70 (Ki)

κ-opioid

219.47 (Ki)

Voir tous les produits spécifiques à Isoform Opioid Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	28.7 nM Compound: 2	Agonist activity at human nociceptin receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis Agonist activity at human nociceptin receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis	[PMID: 23623415]
CHO	EC₅₀	29 nM Compound: 2	Agonist activity at human mu opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis Agonist activity at human mu opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis	[PMID: 23623415]
CHO	EC₅₀	<10000 nM Compound: 2	Agonist activity at human kappa opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis Agonist activity at human kappa opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis	[PMID: 23623415]

In Vivo

SR 16434 (10, 30 mg/kg; s.c.; single-dose) produces dose-dependent increase in tail-flick latency and induces antinociception^[1].
SR 16434 (10, 30 mg/kg; s.c. once daily for 9 days) produces an increase in tail-lick latency across days, induces conditioned place preference, and decreases global activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

20 to 25 g male ICR mice^[1]
Dosage:

10, 30 mg/kg
Administration:

s.c. for single-dose
Result:

Produced dose-dependent increase in tail-flick latency and induced antinociception.

Animal Model:

20 to 25 g male ICR mice^[1]
Dosage:

10, 30 mg/kg
Administration:

s.c. once daily for 9 days
Result:

Produced an increase in tail-lick latency across days, induced conditioned place preference, and decreased global activity.

Chemical Information

CAS No. 857262-16-9
Masse moléculaire 338.49
Formule C₂₂H₃₀N₂O
SMILES

O=C1N(C2CCN(C3C4CCCC3CCC4)CC2)C5=C(C=CC=C5)C1
Synonyms

SR-16435 free base
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Khroyan TV, et al. SR 16435 [1-(1-(bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], a novel mixed nociceptin/orphanin FQ/mu-opioid receptor partial agonist: analgesic and rewarding properties in mice. J Pharmacol Exp Ther. 2007;320(2):934-943. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Pureté et documentation
Références

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SR-16434

Voir tous les produits spécifiques à Isoform Opioid Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

SR-16434 Related Classifications

HY-122681 Related Classifications