SS148
SS148 is a dual inhibitor of nsp14/nsp16 MTase. SS148 significant inhibits nsp10–nsp16 with an IC50 of 1.2 μM.
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- CAS No.: 1985669-27-9
- Formule: C16H20N6O5S
- Masse moléculaire:408.43
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Chemical Information
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CAS No. 1985669-27-9
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Masse moléculaire 408.43
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Formule C16H20N6O5S
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SMILES
N#CC1=CN(C2=NC=NC(N)=C21)[C@@H]3O[C@H](CSCC[C@@H](C(O)=O)N)[C@@H](O)[C@H]3O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
[1]. Nigam A, et al. Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors. bioRxiv [Preprint]. 2023 Nov 13:2023.10.03.560722. [Content Brief]
[2]. Klima M, et al. Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16. Protein Sci. 2022 Sep;31(9):e4395. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SS148 Related Classifications
HY-124654 Related Classifications
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