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Cat. No.: HY-100010

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Sulfathiourea

Sulfathiourea is an inhibitor of Pneumocystis carinii dihydropteroate synthetase (dihydropteroate synthetase), with an IC₅₀ of 0.022 μM and a K_i of 16.5 nM. Sulfathiourea blocks folate biosynthesis by inhibiting the enzyme that links 7,8-dihydro-6-hydroxymethylpterin pyrophosphate with p-aminobenzoic acid to form dihydropteroate. Sulfathiourea can be used in research related to *Pneumocystis carinii* pneumonia.

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CAS No.: 515-49-1
Formule: C₇H₉N₃O₂S₂
Masse moléculaire:231.29

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Please store the product under the recommended conditions in the Certificate of Analysis.

Sulfathiourea Chemical Structure

CAS No.: 515-49-1

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One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique
- Description
- In Vitro
Chemical Information
Protocole (1)
Pureté et documentation
Références
Calculators
Help & FAQs
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Activité biologique

Description

In Vitro

Sulfathiourea potently inhibits recombinant *Pneumocystis carinii* dihydropteroate synthase, with an IC₅₀ of 22 nM and a K_i of 16.5 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 515-49-1
Masse moléculaire 231.29
Formule C₇H₉N₃O₂S₂
SMILES

O=S(=O)(NC(=S)N)C1=CC=C(N)C=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Hong YL, et al. Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob Agents Chemother. 1995;39(8):1756-1763. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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