T-2307 diformate
Based on 1 Customer Validation
T-2307 diformate is an antifungal agent with blood-brain barrier penetration. T-2307 diformate exhibits broad-spectrum antifungal activity against Candida species, including echinocandin-resistant strains, Cryptococcus neoformans, Cryptococcus gattii, and some Aspergillus species. T-2307 diformate selectively targets fungal mitochondrial respiratory chain complexes III and IV, causing collapse of the fungal mitochondrial membrane potential and exerting fungicidal or fungistatic effects. T-2307 diformate can be used in research related to fungal infections such as invasive candidiasis, cryptococcosis, and aspergillosis.
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- Formule: C27H39N5O6
- Masse moléculaire:529.63
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
T-2307 (0.0078-0.0625 mg/L; 72 h) diformate exhibits potent in vitro antifungal activity against C. gattii (GM MIC = 0.0394 mg/L)[2].
T-2307 diformate exhibits potent antifungal activity against Candida spp. (MIC range, 0.00025-0.0078 μg/mL), Cryptococcus neoformans (MIC range, 0.0039-0.0625 μg/mL), and Aspergillus spp. (MIC range, 0.0156-4 μg/mL)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
T-2307 (1-2 mg/kg/day; subcutaneous injection; once daily; 7 days) diformate significantly reduces viable counts in the lungs and brain in a progressive mouse model of intranasal pulmonary C. gattii infection[2].
T-2307 (subcutaneous injection; once daily for 7 consecutive days) diformate shows an ED50 = 0.00755 mg/kg in the mouse disseminated candidiasis model, an ED50 = 0.117 mg/kg in the cryptococcosis model, and an ED50 = 0.391 mg/kg in the aspergillosis model[3].
T-2307 (0.0025-3 mg/kg; subcutaneous injection, administered 2 h post-infection, once daily for 7 consecutive days) diformate dose-dependently increases the survival rate of neutropenic mouse models of disseminated candidiasis, systemic cryptococcosis, and systemic aspergillosis induced by Candida albicans TIMM 1623, Cryptococcus neoformans ATCC 90112, and Aspergillus fumigatus IFM 46895, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Masse moléculaire 529.63
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Formule C27H39N5O6
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SMILES
N=C(N)C1=CC=C(C=C1)OCCCN2CCC(CC2)CCCOC3=CC=C(C=C3)C(N)=N.OC=O.OC=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
In Vitro:
1 M HCl : ≥ 100 mg/mL (188.81 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureté et documentation
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Fiche technique (278 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Wiederhold NP, et al. The novel arylamidine T-2307 maintains in vitro and in vivo activity against echinocandin-resistant Candida albicans. Antimicrobial agents and chemotherapy. 2015 Feb;59(2):1341-3. [Content Brief]
[2]. Nishikawa H, et al. In vitro and in vivo antifungal activities of T-2307, a novel arylamidine, against Cryptococcus gattii: an emerging fungal pathogen. The Journal of antimicrobial chemotherapy. 2017 Jun 01;72(6):1709-1713. [Content Brief]
[3]. Mitsuyama J, et al. In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. Antimicrobial agents and chemotherapy. 2008 Apr;52(4):1318-24. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 1 M HCl | 1 mM | 1.8881 mL | 9.4406 mL | 18.8811 mL | 47.2028 mL |
| 5 mM | 0.3776 mL | 1.8881 mL | 3.7762 mL | 9.4406 mL | |
| 10 mM | 0.1888 mL | 0.9441 mL | 1.8881 mL | 4.7203 mL | |
| 15 mM | 0.1259 mL | 0.6294 mL | 1.2587 mL | 3.1469 mL | |
| 20 mM | 0.0944 mL | 0.4720 mL | 0.9441 mL | 2.3601 mL | |
| 25 mM | 0.0755 mL | 0.3776 mL | 0.7552 mL | 1.8881 mL | |
| 30 mM | 0.0629 mL | 0.3147 mL | 0.6294 mL | 1.5734 mL | |
| 40 mM | 0.0472 mL | 0.2360 mL | 0.4720 mL | 1.1801 mL | |
| 50 mM | 0.0378 mL | 0.1888 mL | 0.3776 mL | 0.9441 mL | |
| 60 mM | 0.0315 mL | 0.1573 mL | 0.3147 mL | 0.7867 mL | |
| 80 mM | 0.0236 mL | 0.1180 mL | 0.2360 mL | 0.5900 mL | |
| 100 mM | 0.0189 mL | 0.0944 mL | 0.1888 mL | 0.4720 mL |
T-2307 diformate Related Classifications
HY-114220A Related Classifications
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Keywords
- T-2307 diformate
- Fungal
- Mitochondrial Metabolism
- Aspergillus fumigatus
- fungal mitochondrial membrane potential
- Candida spp.
- Cryptococcus gattii
- murine model of invasive candidiasis
- murine model of intranasal pulmonary C. gattii infection
- Candida albicans
- echinocandin-resistant Candida albicans
- Cryptococcus neoformans
- fluconazole-resistant
- Inhibitor
- inhibitor
- inhibit