TAT-MEK1
TAT-MEK1 is an inhibitor ofERK2, consisting of TAT and MEK1 (N-terminal), TAT (YGRKKRRQRRR) derived from human immunodeficiency (HIV-1) transcriptional trans activator (TAT), is a cell-penetrating peptide. TAT-MEK1 IC50 in vitro for ERK2 is 29 μM.
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- CAS No.: 566872-16-0
- Formule: C136H241N53O31S
- Masse moléculaire:3146.77
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
TAT-MEK1 (100 μM, 30 min) can inhibit luciferase activity in NIH.3T3 and PC12 cells , and inhibit the activation of ERK2sup>[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NIH 3T3 and PC12
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Concentration:100 μM
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Incubation Time:30 min
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Result:Inhibited luciferase activity in cells and the activity of ERK2.
Chemical Information
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CAS No. 566872-16-0
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Masse moléculaire 3146.77
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Formule C136H241N53O31S
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Sequence
Gly-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-NH2
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Sequence Shortening
GYGRKKRRQRRRGMPKKKPTPIQLNP-NH2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Lukanowska M, et al. Bioportides: bioactive cell-penetrating peptides that modulate cellular dynamics. Biotechnol J. 2013 Aug;8(8):918-30. [Content Brief]
[2]. Kelemen BR, et al. Selective in vivo inhibition of mitogen-activated protein kinase activation using cell-permeable peptides. J Biol Chem. 2002 Mar 8;277(10):8741-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TAT-MEK1 Related Classifications
HY-P10074 Related Classifications
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