Trimazosin
Trimazosin is an orally active, quinazoline derivative which is structurally related to prazosin. Trimazosin shows hypotensive effect by selectively block α1-adrenoceptors.
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- CAS No.: 35795-16-5
- Formule: C20H29N5O6
- Masse moléculaire:435.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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α1-adrenergic receptor |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Conscious spontaneously hypertensive rats (SHR)[3]
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Dosage:10–30 mg/kg
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Administration:Subcutaneous administration, once
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Result:Produced graded decreases in blood pressure.
Chemical Information
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CAS No. 35795-16-5
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Masse moléculaire 435.47
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Formule C20H29N5O6
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SMILES
O=C(N1CCN(CC1)C2=NC3=C(C=C(C(OC)=C3OC)OC)C(N)=N2)OCC(C)(C)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. J Vincent, et al. The cardiovascular effects of trimazosin and prazosin in the rabbit. Clin Exp Pharmacol Physiol. 1986 Aug;13(8):593-608. [Content Brief]
[2]. H L Elliott, et al. Trimazosin in normotensive subjects. Clin Pharmacol Ther. 1984 Feb;35(2):156-60. [Content Brief]
[3]. J. P. Buyniski, et al. Effects of Tiodazosin, Prazosin, Trimazosin and Phentolamine on Blood Pressure, Heart Rate and on Pre- and Postsynaptic α-Adrenergic Receptors in the Rat. Clinical and Experimental Hypertension , 1980, Vol.2(6), p.1039-1066. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trimazosin Related Classifications
HY-106554 Related Classifications
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