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Cat. No.: HY-P99229

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Upifitamab

(Synonyms: XMT-1535; Upinitatug)

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Upifitamab is a humanized monoclonal antibody targeting NaPi2b. Upifitamab can be used to synthesize ADC such as Upfitamab rilsodotin. Upfitamab rilsodotin can be used in research for solid tumors including high-grade serious epithelial ovarian, fallopian tube and primary peritoneal cancer (OC). Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 99%
CAS No.: 2254118-43-7
Masse moléculaire:145.06 kDa

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Upifitamab Chemical Structure

CAS No.: 2254118-43-7

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Activité biologique
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Essai clinique
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Publications (2)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

NaPi2b/SLC34A2

In Vitro

Upifitamab is the monoclonal antibody part of the ADC Upfitamab rilsodotin, which can be used in solid tumor research including high-grade serious epithelial ovarian, fallopian tube and primary peritoneal cancer (OC)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

10568 [NCBI]

Accession

O95436

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

IgG1-kappa

Application

ELISA, FACS, Functional assay

Chemical Information

CAS No. 2254118-43-7
Appearance Liquid
Masse moléculaire 145.06 kDa
Color Colorless to light yellow
SMILES

[Upifitamab]
Synonyms

XMT-1535; Upinitatug
Livraison

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Journal Impact Factor

Mol Cancer Ther

TUB-040, a homogenous and hydrophilic NaPi2b-targeting ADC with stably linked exatecan, exhibits long-lasting anti-tumor activity and a well-tolerated safety profile. [Abstract]

2025 Jul 16. PMID: 40667801
Patent

US20240190958A1.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (258 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Références

[1]. Theresa L. Werner, et al., 32 UPGRADE: phase 1 combination trial of the NaPi2b-directed antibody drug conjugate (ADC) upifitamab rilsodotin (UpRi; XMT-1536) in patients with ovarian cancer, Gynecologic Oncology Reports, Volume 44, Supplement 2, 2022, Page S16, ISSN 2352-5789.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Upifitamab

2 Cited Publications

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Activité biologique
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Essai clinique
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Publications (2)
Pureté et documentation
Références

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Upifitamab

Antibody Inhibitor Library

Publications Citing Use of MedChemExpress (MCE) Upifitamab

Activité biologique

Chemical Information

Publications (2)

Pureté et documentation

Références

Calculators

Help & FAQs

Upifitamab

Cell-ATP Viability Detection Kit

Protein A Agarose

HOLO Human Interleukin-2 (IL-2) Detection Kit

Bradford Protein Assay Kit

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Antibody Inhibitor Library

Publications Citing Use of MedChemExpress (MCE) Upifitamab

Activité biologique

Chemical Information

Publications (2)

Pureté et documentation

Références

Calculators

Help & FAQs

Upifitamab Related Classifications

HY-P99229 Related Classifications