VE-465
VE-465 is an Aurora kinase inhibitor. VE-465 induces cancer cell apoptosis. VE-465 has anticancer effects in multiple tumor models.
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- CAS No.: 639089-73-9
- Formule: C22H28N8OS
- Masse moléculaire:452.58
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Voir tous les produits spécifiques à Isoform Aurora Kinase
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COLO 205 | IC50 |
0.024 μM
Compound: 20
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Antiproliferative activity against human COLO205 cells assessed as inhibition of thymidine uptake after 96 hrs
Antiproliferative activity against human COLO205 cells assessed as inhibition of thymidine uptake after 96 hrs
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[PMID: 19320489] |
| COLO 205 | IC50 |
0.024 μM
Compound: 40
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Antiproliferative activity against human COLO205 cells by [3H]thymidine uptake assay
Antiproliferative activity against human COLO205 cells by [3H]thymidine uptake assay
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[PMID: 19447622] |
Chemical Information
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CAS No. 639089-73-9
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Masse moléculaire 452.58
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Formule C22H28N8OS
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SMILES
CCC(NC1=CC=C(C=C1)SC2=NC(NC3=NNC(C)=C3)=CC(N4CCN(CC4)C)=N2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Lin ZZ, et al. The Aurora kinase inhibitor VE-465 has anticancer effects in pre-clinical studies of human hepatocellular carcinoma. J Hepatol. 2009 Mar;50(3):518-27. [Content Brief]
[2]. Evans R, et al. Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells. Leuk Lymphoma. 2008 Mar;49(3):559-69. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VE-465 Related Classifications
HY-123697 Related Classifications
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